In this paper, we consider the eigenvalue PDE problem of infinitesimal generators metastable diffusion processes. We propose a numerical algorithm based on training artificial neural networks for solving leading eigenvalues and eigenfunctions such high-dimensional problem. The is able to find multiple eigenpairs by single task. It useful in understanding dynamical behaviors processes large time...

Dipeptide mimetic of the nerve growth factor (NGF) loop 4, hexamethylenediamide bis-(N-monosuccinyl- glutamyl-lysine) (GK-2), was synthesized at the V.V. Zakusov Scientific Research Institute of Pharmacology of the Russian Academy of Medical Sciences. GK-2 exhibited in vitro neuroprotective activity at nanomolar concentrations, was efficient in animal models of the Parkinson's disease, ischemic...

Previously human blood monocytes were shown to become tumoricidal when treated in vitro with lipopolysaccharide, muramyl dipeptide analogue, or liposomes containing muramyl dipeptide analogue. In this study the ability of human blood monocytes activated to the antitumor state by these macrophage activators to produce interleukin 1 (IL-1) was examined. Blood monocytes separated by centrifugal el...

Dipeptide and tripeptide derivatives containing a statine residue were synthesized as inhibitors of human renin. ES-305, bis[(1-naphthyl)methyl]acetyl(BNMA)-histidyl-statine 2(S)-methylbutylamide was found to be a highly potent inhibitor of human renin with a Ki value of 1.7 X 10(-9) M. Dipeptide derivatives with the BNMA group at the N-terminal (BNMA-Val-Sta-isoleucinol [ES-313], BNMA-Leu-Sta-...

Wenzel, Uwe, Daniela Diehl, Martina Herget, and Hannelore Daniel. Endogenous expression of the renal high-affinity H1-peptide cotransporter in LLC-PK1 cells. Am. J. Physiol. 275 (Cell Physiol. 44): C1573–C1579, 1998.—The reabsorption of filtered diand tripeptides as well as certain peptide mimetics from the tubular lumen into renal epithelial cells is mediated by an H1-coupled high-affinity tra...

The conditions for the preparation of laurylsarcosyltaurine from lauric acid and sarcosyltaurine, a crystalline dipeptide, are described. The preparation of sarcosyltaurine from the reaction of taurine and the mixed anhydride of benzyloxycarbonylsarcosine and isobutyl chloroformate is also described.

A supramolecular hydrogel formed by dipeptide Gly-Ala linked with biphenyl-substituted tetrazole serves not only as a 3D matrix for live cells, but also as a carrier to deliver microRNA into the encapsulated cells.

An amphiphilic dipeptide (1) bearing pyrene and phenylboronic acid was demonstrated as a unique example of a ratiometric sensing system for sugars by reversibly converting the peptide aggregates into the monomer form of the complex with sugars in aqueous solutions.

Integration of photo-sensitive spiropyran with dipeptide d-Ala-d-Ala in one small molecule resulted in a hydrogelator which can form supramolecular hydrogel with responses not only to light but to ligand-receptor interaction.

Amino acid-derived propargylic amides are cyclised in a one-pot, Au(III)-catalysed operation to yield 5-bromomethyl oxazoles. These compounds are further elaborated to bis-heterocycles, dipeptide mimics and more.