Drug abuse (DA) and addiction is a complex illness, broadly viewed as a neurobiological impairment with genetic and environmental factors that influence its development and manifestation. Abused substances can disrupt the activity of neurons by interacting with many proteins, particularly G-protein coupled receptors (GPCRs). A few medicines that target the central nervous system (CNS) can also ...

Objective: to culturally adapt The Barriers to Research Utilization Scale and to analyze the metric validity and reliability properties of its Brazilian Portuguese version. Method: methodological research conducted by means of the cultural adaptation process (translation and back-translation), face and content validity, construct validity (dimensionality and known groups) and reliability anal...

BACKGROUND Chronic inflammation, changes in body composition, and declining physical function are hallmarks of the ageing process. The aim of the present study was to provide a preliminary characterisation of the relationship among these age-related phenomena via multivariate modelling. METHODS Thirty-five old adults (OAs) and 17 young adults (YAs) were enrolled. The volume of skeletal muscle...

BACKGROUND Decision aids can be used to support shared decision making (SDM). A patient-oriented treatment decision aid (DA) was developed for type 2 diabetes but its use by general practice staff appeared to be limited. OBJECTIVES To explore views of practice staff towards SDM and the DA. DESIGN A mixed-methods study within the Dutch PORTDA-diab trial. SETTING AND PARTICIPANTS Included w...

The paper describes the outline of 2D-discrete cosine change (DCT) which is generally utilized as a part of picture and video pressure calculations. The target of this paper is to plan a completely parallel distributed arithmetic (DA) architecture for two dimensional (2D) DCT to be implemented in Xilinx. DCT requires extensive measure of scientific calculations including multiplications and col...

We propose a conversational agent that can act as a virtual representative of a web site interacting with visitors using natural languages. The agent consists of three main components: dialogue act categorization, structured pattern matching, and knowledge construction and representation. Dialogue acts are identified by automata which accept sequences of keywords defined for each of the dialogu...

Procedures to lesion dopamine (DA) neurons innervating the rat caudate-putamen (CP) in a partial, graded fashion are described in this study. The goal is to provide a lesion model that supports intra-animal comparisons of voltammetric recordings used to investigate compensatory adaptation of DA neurotransmission. Lesions exploited the topography of mesostriatal DA neurons, microinjections of th...

Proper dynamic equation constraints in data assimilation (DA) systems can help improve balance of analyzed atmospheric state. The formulation of ensemble-variational DA algorithms allows for easy incorporation of such constraints, but their impacts within such DA systems have been little studied. A dynamic constraint based on the steady momentum equations is incorporated into the WRF (Weather R...

In this document we define the Dependability Analysis Modelling profile, namely DAM profile. The process of deriving a DAM profile has been going through several steps. First of all, an in depth analysis of the literature has been carried out, in order to collect in a checklist the information requirements for the profile. Then a two-step approach for the profile definition has been followed. I...

The possibility to generate dopaminergic (DA) neurons from pluripotent stem cells represents an unlimited source of material for tissue engineering and cell therapy for neurodegenerative disease. We set up a protocol based on the generation of size-calibrated neurospheres for a rapid production (3 weeks) of a high amount of DA neurons (>60%) oriented toward a midbrain-like phenotype, characteri...