PD 404182 [6H-6-imino-(2,3,4,5-tetrahydropyrimido)[1,2-c]-[1,3]benzothiazine], a heterocyclic iminobenzothiazine derivative, is a member of the Library of Pharmacologically Active Compounds (LOPAC) that is reported to possess antimicrobial and anti-inflammatory properties. In this study, we used biochemical assays to screen LOPAC against human dimethylarginine dimethylaminohydrolase isoform 1 (...

OBJECTIVE Non-steroidal anti-inflammatory drugs (NSAIDs) have shown antibacterial activity in some recent studies. The aim of this study was to evaluate the antibacterial effect of diclofenac against Enterococcus faecalis (E. faecalis) as a resistant endodontic bacterium in comparison with ibuprofen, calcium hydroxide and amoxicillin. MATERIALS AND METHODS The antibacterial activity of materi...

This study evaluated the antimicrobial and antioxidant activities of crude peptide extracted from Galatea paradoxa (G. paradoxa) and Patella rustica (P. rustica). The extracts were tested against eight strains of bacteria (Escherichia coli, Staphylococcus aureus, Bacillus subtilis, Salmonella typhi, Enterococcus feacalis, Klebseilla pneumoniae, Streptococcus pneumoniae, Pseudomonas aeruginosa) ...

Methicillin Resistant S. aureus poses serious threat to human health since the mortality and morbidity rate due to S. aureus infection is significant. In the present study, a total of 37 S. aureus strains isolated from 1078 clinical were tested against various antibiotics. Antibiotic susceptibility of the isolated S. aureus was carried out using disk diffusion method. The MIC and MBC of differe...

Hasenclever, H. F. (U. S. Public Health Service, Bethesda, Md.), and William O. Mitchell. Antigenic studies of Candida. I. Observations of two antigenic groups in Candida albicans. J. Bacteriol. 82:570-573. 1961.-Two distinct antigenic groups, detected by tube agglutination, have been observed among strains of Candida albicans. Adsorption of an antiserum with a heterologous strain did not remov...

BACKGROUND Immunoassay is unsatisfactory for measuring the testosterone concentrations typically found in women. Bench-top tandem mass spectrometers are a viable alternative technology for measurements in the clinical laboratory. METHODS We used stable-isotope dilution liquid chromatography-tandem mass spectrometry (ID/LC-MS/MS) to measure testosterone in plasma and serum. The sample volume w...

A primary means to reduce environmental levels of diesel particulate matter (DPM) exposure to miners is to reduce the amount of DPM emission from the engine. A quick and economic method to estimate engine particulate emission levels has been developed. The method relies on the measurement of pressure increase across a filter element that is briefly used to collect a DPM sample directly from the...

Evaluations of several commercial presence-absence (P-A) test kits were performed over a 6-month period in 1990 by using the Ontario Ministry of the Environment (MOE) P-A test for comparison. The general principles of the multiple-tube fermentation technique formed the basis for conducting the product evaluations. Each week, a surface water sample was diluted and inoculated into 25 99-ml diluti...

The antibody titer of a serum has usually been given in terms of the highest dilution at which it will agglutinate, hemolyze, or precipitate the antigen, in terms of the volume of toxin it will neutralize, in terms of the optimal proportion in which flocculation with antigen takes place, in terms of mouse protection-all relative and often inaccurate measures giving no idea whatsoever of the act...

OBJECTIVE To determine the baseline Widal titres in apparently healthy children in Davangere. METHODS Cross-sectional study was done on 250 children. Widal titers were found using tube agglutination test. RESULTS Out of 250,64.2% had a titre of less than 1:20,22.4% had a titre equal to 1:20,9.6% had a titre of 1:40 and 3.6% had a titre of 1:80 to 'O' antigen and 67.2% had a titre of less th...