نتایج جستجو برای: digestive protease type

تعداد نتایج: 1398303  

Journal: :American journal of physiology. Gastrointestinal and liver physiology 2016
Laura E Edgington-Mitchell Thomas Wartmann Alicia K Fleming Vasilena Gocheva Wouter A van der Linden Nimali P Withana Martijn Verdoes Luigi Aurelio Daniel Edgington-Mitchell TinaMarie Lieu Belinda S Parker Bim Graham Thomas Reinheckel John B Furness Johanna A Joyce Peter Storz Walter Halangk Matthew Bogyo Nigel W Bunnett

Pancreatitis is an inflammatory disease of the pancreas characterized by dysregulated activity of digestive enzymes, necrosis, immune infiltration, and pain. Repeated incidence of pancreatitis is an important risk factor for pancreatic cancer. Legumain, a lysosomal cysteine protease, has been linked to inflammatory diseases such as atherosclerosis, stroke, and cancer. Until now, legumain activa...

Journal: :Aging 2021

Traditional Chinese medicine (TCM) had demonstrated effectiveness in the prevention and control of COVID-19. Statistics showed that Ephedra Glycyrrhiza were frequently used treatment We hypothesized Ephedra-Glycyrrhiza drug pair is a potential choice for Here, 112 active compounds identified from via network pharmacology approach. enrichment analysis these might participate cAMP, PI3K-Akt, JAK-...

2012
Fernando Álvarez-Alfageme Christoph Lüthi Jörg Romeis

Genetically modified (GM) legumes expressing the α-amylase inhibitor 1 (αAI-1) from Phaseolus vulgaris L. or cysteine protease inhibitors are resistant to several bruchid pests (Coleoptera: Chrysomelidae). In addition, the combination of plant resistance factors together with hymenopteran parasitoids can substantially increase the bruchid control provided by the resistance alone. If the strateg...

Journal: :Environmental biosafety research 2007
Maureen O'Callaghan Michael Brownbridge Wendy B Stilwell Emily M Gerard Elisabeth P J Burgess Emma I Barraclough John T Christeller

Effects of tobacco genetically modified to express the protease inhibitor bovine spleen trypsin inhibitor (BSTI) were examined in laboratory assays against three earthworm and one collembolan species. BSTI is a serine protease inhibitor that can bind to the digestive trypsins of insects feeding on modified plants, resulting in reduced growth and survival. Protease inhibitors are active against ...

2013
Donelly A. van Schalkwyk Kevin J. Saliba Giancarlo A. Biagini Patrick G. Bray Kiaran Kirk

The intraerythrocytic malaria parasite is susceptible to oxidative stress and this may play a role in the mechanism of action of some antimalarial agents. Here we show that exposure of the intraerythrocytic malaria parasite to the oxidising agent hydrogen peroxide results in a fall in the intracellular ATP level and inhibition of the parasite's V-type H(+)-ATPase, causing a loss of pH control i...

Journal: :Journal of Molecular Docking 2021

SARS-CoV-2, a new type of Coronavirus, has affected more millions people worldwide. From the spread this infection, many studies related to virus and drug designing for treatment have been started. Most target SARS-CoV-2 main protease, spike protein SASR-CoV-2, some are targeting human furin protease. In current work, we chose clinically used molecules remdesivir, favipiravir, lopinavir, hydrox...

Journal: :International Journal of Pharmacy and Pharmaceutical Sciences 2023

Objective: This study was aimed to access one of the hidden ANF in Indian bean and assessment its antioxidant, immunomodulatory, antiangiogenic, anti-cancer properties. Methods: beans were processed evaluated for presence through HA activity. Bean-ANF partially purified by ammonium sulfate precipitation (ASP) dialysis. Obtained Partially Purified bean-ANF (PPb-ANF) resolved on 12% SDS-PAGE, ana...

Journal: :Journal of Marine Science and Engineering 2022

The present study evaluated the influence of different commercial agricultural by-products as a carbon source in bifloc-based (BFT) culture system on growth performance, whole-body proximate composition, digestive enzyme activities, gut microbial abundance, and hepatopancreas histology Pacific whiteleg shrimp, Litopenaeus vannamei post larvae (Pls). Three groups were designed, first group was c...

Journal: :Neotropical Ichthyology 2021

ABSTRACT In the Southeast of Mexico, there are many native cichlids with commercial interest such as redhead cichlid (Vieja melanurus) and twoband (V. bifasciata), which have a great local demand excellent meat quality. However, it is necessary to implement their culture based on nutrition studies digestive biochemistry. This study’s objective was characterize these two cichlids’ proteases (pH,...

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