A rare case of solitary diffuse large B-cell lymphoma arising from the lumbar spinal nerve root is reported. A 37-year-old man presented with a 3-month history of progressive numbness and paraparesis in both legs. The initial diagnosis was benign primary intradural extramedullary tumor including schwannoma and meningioma. Histopathological examination revealed diffuse large B-cell lymphoma. Whi...

introduction: most b-cell malignancies are diagnosed based on morphologic and immunohistochemical criteria. some cases, however, still present a challenge for the pathologist to discriminate between reactive hyperplasia and neoplastic disorders. molecular techniques can be used as a helpful diagnostic tool in these cases. in this study, we assessed the value of polymerase chain reaction (pcr) t...

BCL6. Blood. 2000;96:2907-2909. 5. Kramer MH, Hermans J, Wijburg E, et al. Clinical relevance of BCL2, BCL6, and MYC rearrangements in diffuse large B-cell lymphoma. Blood. 1998;92: 3152-3162. 6. Ueda C, Akasaka T, Kurata M, et al. The gene for interleukin-21 receptor is the partner of BCL6 in t(3;16)(q27;p11), which is recurrently observed in diffuse large B-cell lymphoma. Oncogene. 2002;21:36...

type that are restricted to the dermal or epidermal region and are without any signs of systemic lymphoma. Most skin non-Hodgkin’s lymphomas (NHL) originate from T cells, and primary cutaneous diffuse large B cell lymphomas (PCDLBCLs) are uncommon (1). PCDLBCLs appear clinically as non-specific multiple palpable nodules or plaques in the subcutaneous tissue (2). PCDLBCLs localized in the head a...

Background: Chronic lymphocytic leukemia (CLL) can transform into fast growing lymphoma for diffuse large B-cell lymphoma (DLBCL) called Richter's syndrome (RS), which is commonly related to an existence of large B-cells with equal or larger size than macrophage nuclei or more than twice those of normal lymphocyte. We conducted a systematic review of the existing literature to assess the clinic...