Although surgery has been the mainstay of treatment for patients with well-differentiated thyroid cancer, the extents of thyroid resection and lymph node dissection adopted in Japan differ from those in other countries. Furthermore, regarding the indications for postoperative radiation therapy and hormonal therapy, and treatment modalities for cancer recurrence, there are marked discrepancies b...

131I treatment is an important management method for patients with differentiated thyroid cancer (DTC). Unsuccessful 131I ablation drastically affects the prognosis of the patients. This study aimed to analyze potential predictive factors influencing the achievement of a disease-free status following the first 131I therapy. This retrospective review included 315 DTC patients, and multiple facto...

Levothyroxine suppressive treatment of solitary thyroid nodules is controversial. A 1-yr prospective randomized placebo-controlled trial was conducted to evaluate the effect of T4 on nodule volume and bone mineral density, and meta-analyses were performed to examine the quantitative synthesis of data from similar designed controlled trials. Forty-five euthyroid patients (42 females, age range: ...

An 82-year-old female with known hypothyroidism was admitted to hospital after being found on the floor. On examination, she was unkempt, confused, bradycardic, hypothermic, and barely arousable. Initial biochemistry revealed a thyroid stimulating hormone (TSH) of >100 mU/L and free thyroxine (FT4) level of 1.5 pmol/L which supported a diagnosis of myxoedema coma. She was resuscitated and comme...

BACKGROUND Suboptimal thyroid hormone replacement may carry harmful health consequences. AIMS Our objectives were to determine the prevalence and factors associated with inadequate replacement in patients receiving treatment with levothyroxine. DESIGN Retrospective general practice audit. METHODS We identified levothyroxine users through electronic searches of primary care records in all ...

Aim: There is a need to evaluate the treatment response in patients who have undergone radioiodine (RIT) for differentiated thyroid cancer. Diagnostic tests that are used this purpose include whole-body scan (WBS) and serum thyroglobulin (Tg) measurement, which most accurate during thyroid-stimulating hormone (TSH) stimulation. However, temporary discontinuation of therapy increase TSH (withdra...

salivary gland involvement is one of the radioiodine therapy complications. salivary gland scintigraphy in quantitative mode can accurately evaluate salivary gland function. methods: salivary gland scintigraphy was performed with tc-99m pertechnetate, at the time of iodine therapy as a basic study and then 3 weeks and 3 months afterwards. ejection fraction (ef) of parotid and submandibular glan...

Thyroid nodules in childhood and adolescence are less prevalent but more often malignant than in adulthood. Malignant nodules are predominantly papillary cancers; benign nodules are mostly solid colloid nodules/adenomas, but can be cystic or due lymphocytic thyroiditis. Previous neck irradiation (nowadays mostly encountered in childhood cancer survivors) is a clear risk factor for developing no...

BACKGROUND Levothyroxine (LT4) and rifampin (RIF) are sometimes used together; however, no clinical studies have assessed the effects of these drugs on thyroid function or the need to adjust LT4 dose. METHODS We retrospectively reviewed the records of 71 Korean patients who started RIF during LT4 treatment. Clinically relevant cases that required dose adjustment according to the American Thyr...

classically includes a group of sex steroid responsive cancers, such as cancers of the breast, endometrium, prostate, and testis, but also other cancers such as thyroid and ovary cancers that are responsive to pituitary hormones (1). Based on this widely accepted concept, at least 35–40% of newly diagnosed cancers fall into this definition (2). This concept has been useful for its clinical impl...