نتایج جستجو برای: differentiated thyroid cancer

تعداد نتایج: 1022220  

2008
SELWYN TAYLOR

Thyroid cancer is a rare disease. Aetiological factors are increased secretion of TSH and exposure of the growing gland to ionizing radiation. Pathological classification is in two main groups: differentiated and undifferentiated. Differentiated is subdivided into papillary, follicular and medullary. Papillary and medullary carcinomas occur in young patients, grow slowly, spread by lymphatics. ...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2017
Cristina Montero-Conde Luis J Leandro-Garcia Xu Chen Gisele Oler Sergio Ruiz-Llorente Mabel Ryder Iñigo Landa Francisco Sanchez-Vega Konnor La Ronald A Ghossein Dean F Bajorin Jeffrey A Knauf Jesse D Riordan Adam J Dupuy James A Fagin

Oncogenic RAS mutations are present in 15-30% of thyroid carcinomas. Endogenous expression of mutant Ras is insufficient to initiate thyroid tumorigenesis in murine models, indicating that additional genetic alterations are required. We used Sleeping Beauty (SB) transposon mutagenesis to identify events that cooperate with HrasG12V in thyroid tumor development. Random genomic integration of SB ...

Journal: :The Journal of clinical endocrinology and metabolism 2016
Sujay Kakarmath Howard T Heller Caroline A Alexander Edmund S Cibas Jeffrey F Krane Justine A Barletta Neal I Lindeman Mary C Frates Carol B Benson Atul A Gawande Nancy L Cho Matthew Nehs Francis D Moore Ellen Marqusee Mathew I Kim P Reed Larsen Norra Kwong Trevor E Angell Erik K Alexander

CONTEXT Mutations in the BRAF and RAS oncogenes are responsible for most well-differentiated thyroid cancer. Yet, our clinical understanding of how BRAF-positive and RAS-positive thyroid cancers differ is incomplete. OBJECTIVE We correlated clinical, radiographic, and pathological findings from patients with thyroid cancer harboring a BRAF or RAS mutation. DESIGN Prospective cohort study. ...

2012
Giuseppe Viglietto Carmela De Marco

Thyroid is a H-shaped gland localised in front of trachea at the base of the neck, whose main functions are the synthesis, the storage and the secretion of thyroid hormones under the control of the hypothalamic–pituitary axis. Thyroid is comprised of spherical follicles filled with colloid that are lined by cuboidal/flat epithelial cells denoted follicular cells (or thyrocytes). The other hormo...

2012
Dae-Heui Lee

Recent studies suggest that immunization with autologous dendritic cells (DCs) results in protective immunity and rejection of established tumors in various human malignancies. The purpose of this study is to determine whether DCs are generated from peripheral blood mononuclear cells (PBMNs) by using cytokines such as F1t-3 ligand (FL), granulocyte macrophage-colony stimulating factor (GM-CSF),...

Journal: :Cancer Imaging 2008
K.T. Wong Frankie P.T. Choi Yolanda Y.P. Lee Anil T. Ahuja

Nuclear medicine plays an integral role in the management of differentiated thyroid cancer. This editorial aims to provide a summary of the current role of radionuclide imaging, including whole body iodine scan and fluorodeoxyglucose (FDG)-positron emission tomography (PET), in the diagnostic work-up and follow-up of patients with thyroid cancer.

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