Combinations of GluR5-GluR7, KA1, and KA2 subunits form kainate receptors, a subtype of excitatory ionotropic glutamate receptors. Isoflurane enhances the action of kainate receptors comprising GluR6 subunits expressed in oocytes. To test whether alterations of the GluR6 subunit gene affect the actions of inhaled anesthetics in vivo, we measured the minimum alveolar concentration of desflurane,...

The interaction between a small dermatan sulphate proteoglycan isolated from human uterine cervix and collagen type I from human and rat skin was investigated by collagen-fibrillogenesis experiments. Collagen fibrillogenesis was initiated by elevation of temperature and pH after addition of proteoglycan, chondroitinase-digested proteoglycan or isolated side chains, and monitored by turbidimetry...

Cabibbo-allowed charmed meson decays into a pseudoscalar meson and an axial-vector meson are studied. The charm to axial-vector meson transition form factors are evaluated in the Isgur-Scora-Grinstein-Wise quark model. The dipole momentum dependence of the D → K transition form factor and the presence of a sizable long-distance W -exchange are the two key ingredients for understanding the data ...

The wide-ranging expression of glutamate receptors in peripheral tissues suggests an unexpectedly wider role(s) of l-glutamate as an intercellular signaling molecule. However, the peripheral glutamatergic system is poorly understood, partly because the sites of l-glutamate signal appearance are less well characterized. Vesicular glutamate transporters (VGLUTs) are potential probes for the sites...

Mice with global deletion of one brain-derived neurotrophic factor (BDNF) allele or with forebrain-restricted deletion of both alleles show elevated aggression, but this phenotype is accompanied by other behavioral changes, including increases in anxiety and deficits in cognition. Here we performed behavioral characterization of conditional BDNF knockout mice generated using a Cre recombinase d...

Define the height function h(a) = min{k + (ka mod p) : k = 1, 2, . . . , p − 1} for a ∈ {0, 1, . . . , p − 1.} It is proved that the height has peaks at p, (p+1)/2, and (p+c)/3, that these peaks occur at a = [p/3], (p−3)/2, (p− 1)/2, [2p/3], p − 3, p− 2, and p − 1, and that h(a) ≤ p/3 for all other values of a. 1. Heights on finite projective spaces Let p be an odd prime and let Fp = Z/pZ and F...

Frequency-dependent electrical conductivities of solutions of aqueous strontium hydroxide and strontium chloride have been measured from T = 295 K to T = 625 K at p = 20 MPa, over a very wide range of ionic strength (3 × 10(-5) to 0.2 mol kg(-1)), using a high-precision flow AC conductivity instrument. Experimental values for the concentration-dependent equivalent conductivity, Λ, of the two el...

For any field k, Milnor [Mi] defined a sequence of groups K 0 (k), K M 1 (k), K M 2 (k), . . . which later came to be known as Milnor K-groups. These were studied extensively by Bass and Tate [BT], Suslin [Su], Kato [Ka1], [Ka2] and others. In [Som], Somekawa investigates a generalization of this definition proposed by Kato: given semi-abelian varieties G1, . . . , Gs over a field k, there is a...

Synaptic activity causes significant fluctuations in proton concentrations in the brain. Changes in pH can affect neuronal excitability by acting on ligand-gated channels, including those gated by glutamate. We show here a subunit-dependent regulation of native and recombinant kainate receptors by physiologically relevant proton concentrations. The effect of protons on kainate receptors is volt...