BACKGROUND Carbonic anhydrases (CAs), a group of metalloenzymes, are involved in numerous physiological and pathological processes such as acid-base balance, gluconeogenesis, lipogenesis, ureagenesis, electrolyte secretion in various tissues, bone resorption and calcification, and tumorigenicity. In the current study, we aimed to determine and compare possible alterations in the activity of car...

OBJECTIVES The menstrual cycle is characterised by cyclical fluctuations in oestrogens, progesterone and androgens. Changes in hormone levels in the premenstrual phase with the decline in progesterone trigger a physiological reaction which culminates in menstruation. This process is accompanied in many women by various symptoms such as pelvic pain, headache, mood disorders and gastrointestinal ...

BACKGROUND This double-blind trial investigated the efficacy and safety of estradiol valerate/dienogest (E(2)V/DNG) for the treatment of heavy menstrual bleeding without recognizable organic pathology. METHODS Otherwise healthy women with idiopathic heavy, prolonged or frequent menstrual bleeding, confirmed during a 90-day run-in phase, were randomized (2:1) according to a permuted-block, com...

Research aim: to determine the clinical efficacy and safety of bioavailable curcumin Longimin® in complex anti-relapse therapy patients with extragenital endometriosis after surgery.Materials methods. Study involved 45 women a mean age 29.3 ± 3.6 years diagnosis endometriosis. After surgical treatment this disease all were prescribed dienogest 2 mg/day for 6 months purpose. that, 22 did not rec...