a topical preparation containing aceclofenac was developed using an o/w microemulsion system. isopropyl myristate was chosen as the oil phase as it showed a good solubilising capacity. pseudo-ternary phase diagrams were used to obtain the concentration ranges of the oil, surfactant (labrasol) and co-surfactant (plurol oleique) for microemulsion formation. five different formulations were formul...

the aim of this investigation was to design and develop nanoemulsions (nes) as novel ophthalmic delivery systems for brinzolamide (bzd). phase behavior of quaternary systems composed of triacetin and capryoltm 90 (selected oils, screened through the solubility studies), various surfactants (namely, cremophor rh 40, brij 35, labrasol and tyloxapol), transcutol p (as co-surfactant) and water a...

normal 0 false false false en-us x-none ar-sa background: robotic needle insertion in biological tissues has been known as one the most applicable procedures in sampling, robotic injection and different medical therapies and operations. objective: in this paper, we would like to investigate the effects of angular velocity in soft tissue insertion procedure by considering force-displacement diag...

objective(s): the objective of this study was to design a topical microemulsion of vit b12 and to study the correlation between internal structure and physicochemical properties of the microemulsions. microemulsions are thermodynamically stable mixtures of water, oil, surfactants and usually cosurfactants with several advantages for topical and transdermal drug delivery. the formulation of micr...

The distribution of structural planes is complex and irregular. How to quickly effectively obtain the occurrence characteristics improve efficiency data processing a key technical issue in plane analysis. paper combined fuzzy equivalent clustering algorithm, rose diagram drawing method, C++ language, developed system for pole rock mass planes, verified practicability through an engineering case...

Given a set of compact sites on a sphere, we show that their spherical Voronoi diagram can be computed by computing two planar Voronoi diagrams of suitably transformed sites in the plane. We also show that a planar furthest-site Voronoi diagram can always be obtained as a portion of a nearest-site Voronoi diagram of a set of transformed sites. Two immediate applications are an O(n logn) algorit...

It is well-known that the Voronoi diagram of points and the power diagram for weighted points, such as spheres, are cell complexes, and their respective dual structures, i.e. the Delaunay triangulation and the regular triangulation, are simplicial complexes. Hence, the topologies of these diagrams are usually stored in their dual complexes using a very compact data structure of arrays. The topo...

Three topics are discussed. A discrete-state, continuous-time random walk with one or more absorption states can be studied by a presumably new method: some mean properties, including the mean time to absorption, can be found from a modified diagram (graph) in which each absorption state is replaced by a one-way cycle back to the starting state. The second problem is a random walk on a diagram ...