BACKGROUND Anti-glycan antibody serologic markers may serve as a useful adjunct in the diagnosis/prognosis of inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC). This meta-analysis/systemic review aimed to evaluate the diagnostic value, as well as the association of anti-glycan biomarkers with IBD susceptible gene variants, disease complications, and th...

Multiple system atrophy (MSA) is a neurodegenerative disease belonging to group of synucleinopathies and characterized by significant autonomic failure, parkinsonian syndrome, cerebellar signs. Diagnostic criteria used currently were updated in 2022. While the clinical method neuroimaging are typically diagnostic MSA, new modalities emerging. Novel candidate biomarkers being intensively thoroug...

BACKGROUND The diagnosis of myelodysplastic syndromes is not always straightforward when patients lack specific diagnostic markers, such as blast excess, karyotype abnormality, and ringed sideroblasts. DESIGN AND METHODS We designed a flow cytometry protocol applicable in many laboratories and verified its diagnostic utility in patients without those diagnostic markers. The cardinal parameter...

Circulating nucleic acids have been shown to have potential as non-invasive diagnostic markers in cancer. We therefore investigated whether microRNAs also have diagnostic utility by comparing levels of tumour-associated MIRN155 (miR-155), MIRN210 (miR-210) and MIRN21 (miR-21) in serum from diffuse large B-cell lymphoma (DLBCL) patients (n = 60) with healthy controls (n = 43). Levels were higher...

Double-stranded anti-DNA antibodies are excellent diagnostic markers and follow-up markers for systemic lupus erythematosus (SLE). Less specific than anti-Sm antibodies, anti-PCNA antibodies or anti-ribosomal P antibodies, they are nevertheless much more common. Their sensitivity and specificity for SLE gives them diagnostic value as they are part of the criteria used by the American Rheumatism...

Cardiovascular disease (CVD), especially heart failure (HF) as its common final pathway, is the leading cause of morbidity and mortality worldwide. Furthermore, oxidative and inflammatory processes represent fundamental underlying mechanisms for the development and progression of HF. Of interest, in recent years the development of markers with diagnostic and prognostic value for this pathology ...

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Background: Cytokeratin 19 Fragment (CYFRA 21-1) is one of the commonly used tumor markers in clinical practice. The examination of CYFRA 21-1 in pleural effusions may help establish the diagnosis of Malignant Pleural Effusion (MPE). However, given the relatively low sensitivity, it is often used in combination with other tumor markers. Thus, we performed this systematic review and meta-analysi...

Aims: Ovarian cancer has the worst prognosis among female genital tract malignancies, but if detected in the early stages, it is one of the most treatable malignancies. The aim of this study was to investigate the diagnostic value of tumor markers compared to ultrasound in the diagnosis of ovarian tumors. Materials and methods: In this cross-sectional-analytical study, 210 women referred to ...