نتایج جستجو برای: diabetic wound

تعداد نتایج: 178367  

Journal: :International wound journal 2011
Douglas R Solway William A Clark Dennis J Levinson

The purpose of this study was to compare the rate of wound healing in diabetic foot ulcers (DFU) using either a microbial cellulose (MC) wound dressing or Xeroform™ Petrolatum gauze. In a parallel, open-label trial in which the primary outcome was the rate of wound healing and the time to wound closure, 15 ulcers in type II diabetic patients received an MC dressing. Wounds in 19 control patient...

Journal: :Annals of the Academy of Medicine, Singapore 2011
Si Jack Chong Adrian Ooi Yee Onn Kok Meng Kwan Tan

Dear Editor, Coverage of poorly vascularised diabetic wounds is an important rising surgical challenge. Failure leads to amputations and increased morbidity. Worldwide, a limb is lost to diabetes every 30 seconds. Diabetic prevalence in Singapore is 8.2% with 13.9% having vasculopathy, 28.8% stage 2 King’s Classifi cation and 700 diabetic amputations every year.1 We highlight how synergistic HB...

Journal: :Seminars in nephrology 2007
Roy Zent Ambra Pozzi

Angiogenesis, the formation of new blood vessels from pre-existing vasculature, plays a key role in both physiologic and pathologic events, including wound healing, cancer, and diabetes. Neovascularization has been implicated in the genesis of diverse diabetic complications such as retinopathy, impaired wound healing, neuropathy, and, most recently, diabetic nephropathy. Diabetic nephropathy is...

Journal: :Annals of the Academy of Medicine, Singapore 2010
Aziz Nather Siok Bee Chionh Audrey Y Y Han Pauline P L Chan Ajay Nambiar

INTRODUCTION This is the fi rst prospective study done locally to determine the effectiveness of vacuum-assisted closure (VAC) therapy in the healing of chronic diabetic foot ulcers. MATERIALS AND METHODS An electronic vacuum pump was used to apply controlled negative pressure evenly across the wound surface. Changes in wound dimension, presence of wound granulation and infection status of di...

Journal: :Foot & ankle international 2011
Bom Soo Kim Woo Jin Choi Mi Kyung Baek Yong Sang Kim Jin Woo Lee

BACKGROUND The purpose of our study was to determine the efficacy of a management algorithm that includes negative pressure wound therapy (NPWT) in diabetic feet with limb-threatening infection. MATERIALS AND METHODS Forty-five septic diabetic feet were treated with NPWT between 2006 and 2008. After emergent abscess evacuation, early vascular intervention was performed if necessary. Debrideme...

2012
Ho Seong Shin Hwa Young Oh

BACKGROUND Complicated diabetic patients show impaired, delayed wound healing caused by multiple factors. A study on wound healing showed that platelet-rich plasma (PRP) was effective in normal tissue regeneration. Nonetheless, there is no evidence that when plateletrich plasma is applied to diabetic wounds, it normalizes the diabetic wound healing process. In this study, we have analyzed matri...

Journal: :Biochemical pharmacology 2009
María D Valls Bruce N Cronstein M Carmen Montesinos

Wound healing is a dynamic and complex process that involves a well-coordinated, highly regulated series of events including inflammation, tissue formation, revascularization and tissue remodeling. However, this orderly sequence is impaired in certain pathophysiological conditions such as diabetes mellitus, venous insufficiency, chronic glucocorticoid use, aging and malnutrition. Together with ...

Journal: :Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2015
Josef Goldufsky Stephen J Wood Vijayakumar Jayaraman Omar Majdobeh Lin Chen Shanshan Qin Chunxiang Zhang Luisa A DiPietro Sasha H Shafikhani

Diabetic foot ulcers are responsible for more hospitalizations than any other complication of diabetes. Bacterial infection is recognized as an important factor associated with impaired healing in diabetic ulcers. Pseudomonas aeruginosa is the most frequently detected Gram-negative pathogen in diabetic ulcers. P. aeruginosa infection has been shown to impair healing in diabetic wounds in a mann...

2014
Xiaozhe Tong Gang Lv Jianhua Huang Yongfen Min Li Yang Pengnian Charles Lin

Vascularization is an important factor that affects diabetic wound healing. There is increasing evidence that myeloid cell lineages play a role in neovascularization. In this study, the efficiency of Gr-1+CD11b+ myeloid cells to home to the site of injury and enhance diabetic wound healing by neoangiogenesis after intravenous administration was investigated. Gr-1+CD11b+ myeloid cells were injec...

Journal: :Diabetes care 1997
E Chantelau

Foot ulcers are a common and devastating complication of diabetes. Many patients with diabetic foot ulcers experience significant disability and ultimately require amputation. Despite attentive management with multiple modalities including surgical debridement, relief of pressure, and other standard measures, many diabetic foot ulcers persist as chronic, nonhealing wounds. Hyperbaric oxygen (HB...

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