Nucleotide metabolism results in the synthesis of the four nucleotides that form DNA. These are further divided in two categories: purines and pyrimidines. Their construction and degradation takes place in a progression of single steps, while different enzymes and cofactors are involved in the process. Beside degradation, there is also a form of reprocessing purine and pyrimidine nucleotides, d...

Nucleotide metabolism results in the synthesis of the four nucleotides that form DNA. These are further divided in two categories: purines and pyrimidines. Their construction and degradation takes place in a progression of single steps, while different enzymes and cofactors are involved in the process. Beside degradation, there is also a form of reprocessing purine and pyrimidine nucleotides, d...

Stimulated by a suggestion of the late Professor Jack D. Dunitz, that perdeuterated Janus face cycloalkanes may be more polar than their unlabelled forms, deuterated isotopologue all cis-1,2,3,4,5,6-hexafluorocyclohexane ([2H6]-1a) and cis-1,2,3,4-tetrafluorocyclopentane ([2H6]-3a) were prepared. Computation at B3LYP−D3 level indicated [2H6]-1a is not its protio form 1, however cyclopentane [2H...

[3,5-2H]Salicylate was obtained by a hydrogen/deuterium exchange reaction carried out in 2H2O. Using this deuterated salicylate as a substrate for salicylate hydroxylase, the product catechol was isolated and characterized with respect to the positions of deuterium retention. Based on nuclear magnetic resonance and mass spectroscopy analyses, the product was identified as [3,5-2H]catechol. It i...

H3 and the deuterated isotopomers are thought to play an important role in interstellar chemistry. The partition functions of H3 , D2H + and D3 are calculated to a temperature of 800 K by explicitly summing the ab initio determined rotation–vibration energy levels of the respective species. These partition functions are used to calculate the equilibrium constants for nine important reactions in...

Starting with assignments of proton nuclear magnetic resonance previously made for oxytocin in deuterated dimethylsulfoxide at 220 MHz, we have assigned resonances for the mammalian antidiuretic hormone, lysine vasopressin. The results demonstrate that spectral assignments of neurohypophyseal hormones and their congeners can, within certain limits, be derived from each other. Comparison of the ...

We report the first detection of triply-deuterated methanol, with 12 observed transitions, towards the low-mass protostar IRAS 16293−2422, as well as multifrequency observations of CH3OH, used to derive the column density of the main isotopomer CH3OH. The derived fractionation ratio [CD3OH]/[CH3OH] averaged on a 10′′ beam is 1.4%. Together with previous CH2DOH and CHD2OH observations, the prese...