BACKGROUND Illicit opiate use has an increasing incidence and prevalence, which increases mortality and morbidity, marginalization, and criminal behaviors, and causes major adverse effects on society. OBJECTIVES This study aimed to investigate and follow the outcome of patients who underwent ultrarapid opiate detoxification (UROD) prospectively. PATIENTS AND METHODS In this randomized clini...

It is now well known that one of the most prominent causes of breast cancer, as well as many other hormone related health problems in both men and women, is excessive estrogen exposure from both endogenous and exogenous sources. Improving estrogen metabolism can be of benefit in women with various conditions and family histories, including a family history of breast, uterine, or ovarian cancer,...

Phenanthrene is the simplest polycyclic aromatic hydrocarbon (PAH) containing a bay region, a feature closely associated with carcinogenicity. We have proposed that measurement of phenanthrene metabolites in human urine could be used to identify interindividual differences in metabolic activation and detoxification of PAH, and that these differences may be related to cancer susceptibility in sm...

The asymmetric transfer hydrogenation (ATH) of imines catalyzed by the Noyori-Ikariya [RuCl(η6-arene)(N-arylsulfonyl-DPEN)] (DPEN=1,2-diphenylethylene-1,2-diamine) half-sandwich complexes is a research topic that is still being intensively developed. This article focuses on selected aspects of this catalytic system. First, a great deal of attention is devoted to the N-arylsulfonyl moiety of the...

Peroxiredoxin-1, a key enzyme in the cellular detoxification pathway, has been identified through a chemoproteomic approach as the main partner of theonellasterone, a marine bioactive metabolite. A combination of chemical and biochemical assays disclosed its mechanism of action at the molecular level.

The title crystal, [Fe(C5H5)2].C12F10, comprises infinite chains of alternating component molecules, linked through face-to-face contacts of nearly parallel cyclopentadienyl and pentafluorophenyl rings. The decafluorobiphenyl molecule has a crystallographic twofold axis and the Fe atom of the ferrocene molecule is on a crystallographic inversion centre, with both cyclopentadienyl rings disordered.

The title compounds, C12H13NO4, are derived from lthreonine and dl-threonine, respectively. Hydrogen bonding in the chiral derivative, (2S/3R)-3-hydroxy-2-(1-oxoisoindolin2-yl)butanoic acid, consists of OÐHacid OalkylÐ H O Cindole chains [O O 2.659 (3) and 2.718 (3) AÊ ], CspÐH O and three CÐH arene interactions. In the (2R,3S/2S,3R) racemate, conventional carboxylic acid hydrogen bonding as cy...

The coassembly of C(60) derivatives through arene-perfluoroarene interactions has been used for the first time to develop millimeter-sized flat crystalline sheets. Time-resolved microwave conductivity (TRMC) measurements exhibited anisotropic features with over double the charge carrier mobility in the direction parallel to the plane of the crystal than perpendicular to the plane. This study de...