contraceptives We have recently reviewed two studies,1 a cohort study conducted in Denmark,2 and a case-control study conducted in The Netherlands,3 in which it was claimed that the risk of venous thromboembolism (VTE) among users of oral contraceptives (OCs) containing desogestrel, gestodene, drospirenone and cyproterone is greater than among users of levonorgestrelcontaining OCs. We concluded...

Our objective was to test the effect of inhibition of thromboxane synthase versus inhibition of cyclooxygenase (COX)-1/2 on pulmonary gas exchange and heart function during simulated pulmonary embolism (PE) in the rat. PE was induced in rats via intrajugular injection of polystyrene microspheres (25 micro m). Rats were randomized to one of three posttreatments: 1) placebo (saline), 2) thromboxa...

Labeled and unlabeled prostacyclin and 6-keto-PGF1, were infused into healthy volunteers; urine was chromatographed on different systems including high pressure liquid chromatography. The peaks obtained by the latter method were derivatized to the methoxime methyl ester trimethyl silyl ether and analyzed by gasliquid chromatography-mass spectrometry. After infusion of prostacyclin the follo...

E1278 CMAJ, December 13, 2011, 183(18) © 2011 Canadian Medical Association or its licensors The lifetime incidence of venous thromboembolism for both men and women is estimated at 1 per 1000. Increasing our understanding of the precipitating risk factors, as well as optimizing the prevention of this condition in high-risk populations, could help to reduce the burden of venous thromboembolism. A...

as age at first intercourse and age at first pregnancy. An association between increasing duration of OC use and risk of cervical cancer and carcinoma in situ was identified. No association was found with age at first OC use. Use of OC for less than 5 years was not associated with increased risk of cervical neoplasia. Women with a total of 5 to 9 years of OC use had almost three times the risk ...

Jasmonates are a growing class of lipid-derived signaling molecules with diverse functions ranging from the initiation of biotic and abiotic stress responses to the regulation of plant growth and development. Jasmonate biosynthesis originates from polyunsaturated fatty acids in chloroplast membranes. In a first lipoxygenase-catalyzed reaction molecular oxygen is introduced to yield their 13-hyd...

In this week’s issue of The BMJ, Vinogradova and colleagues (doi:10.1136/bmj.h2135) report the results of a large study on the effects of combined oral contraceptives on the risk of venous thromboembolism, conducted in two large United Kingdom databases: the Clinical Practice Research Datalink (CPRD) and QResearch. The authors identified over 10 500 cases of VTE in women aged 15-49 years and ar...

STUDY OBJECTIVE To assess age specific incidence and mortality of stroke, acute myocardial infarction (AMI), and idiopathic venous thromboembolism (VTE) associated with use of modern low dose combined oral contraceptives (OCs) and the interaction with smoking. DESIGN Hospital-based case-control study. SETTING Hospitals in Oxford region in the United Kingdom, which covered a defined populati...

BACKGROUND Contraceptive implants, the levonorgestrel-releasing intrauterine system (LNG IUS), and the copperbearing intrauterine device (IUD) are long-acting reversible contraceptives (LARCs) with high contraceptive effectiveness. The cumulative pregnancy rates in the first 3 years of use of LARCs is 0.9 per 100 woman-years. In comparison, the percentages of women experiencing an unintended pr...