ART: antiretroviral therapy CADM: clinically amyopathic dermatomyositis DM: dermatomyositis ILD: interstitial lung disease MDA5: melanoma differentiationeassociated protein 5 MFU: median fluorescence units INTRODUCTION Dermatomyositis (DM) is an idiopathic inflammatory myopathy that can affect children and adults and is characterized by muscle inflammation and characteristic cutaneous findings....

McKittrick-Wheelock syndrome is a rare disease characterized by a large hypersecretory rectosigmoid villous adenoma resulting in persistent large volume diarrhea, electrolyte abnormalities, and renal dysfunction. We report an unusual presentation of this syndrome in a patient who developed persistent diarrhea along with dermatomyositis and rectal prolapse and was later discovered to have a larg...

LL-37, an active form of human cathelicidin exhibits various effects on immunity and inflammation, such as induction inflammatory cells angiogenesis in addition to its antimicrobial activity. Involvement LL-37 the pathogenesis several skin diseases psoriasis rosacea has been described. To search for association other diseases, we focused scleroderma dermatomyositis. Previously, it shown that is...

OBJECTIVES Herpes zoster has been widely described in the context of different systemic autoimmune diseases but not dermatomyositis/polymyositis. Therefore, we analyzed the prevalence, risk factors and herpes zoster outcomes in this population. METHOD A retrospective cohort study of herpes zoster infections in dermatomyositis/polymyositis patients was performed. The patients were followed at ...

OBJECTIVE To understand the use of tumour necrosis factor (TNF)alpha inhibitors in refractory dermatomyositis and polymyositis in an academic centre. METHODS A retrospective study of eight patients with dermatomyositis or polymyositis refractory to corticosteroids and immunosuppressives who were treated with TNF inhibitors between 1998 and 2004. RESULTS 8 patients with dermatomyositis or po...

The inflammatory myopathies, including dermatomyositis, inclusion body myositis, and polymyositis, are poorly understood autoimmune diseases affecting skeletal muscle. Dermatomyositis is a disease mainly of skin and muscle, but may affect lung and other tissues. Proximal or generalized weakness or skin rash are the typical presenting features. Inclusion body myositis has a specific clinical pat...

Background: There are scarce studies in the literature about hyaluronic acid in systemic autoimmune myopathies. oBjectives: To analyze the serum level of hyaluronic acid in patients with dermatomyositis and polymyositis. Methods: Cross-sectional study, single-center, that evaluated hyaluronic acid in 18 dermatomyositis and 15 polymyositis (Bohan and Peter criteria), newly diagnosed, with clinic...

“You can’t manage what you don’t measure.” The world community–led by the IMACS and PRINTO groups–has developed robust core criteria to measure disease activity and damage for Juvenile Dermatomyositis studies. These measures are tremendously useful in clinical practice, and not just for research. More problematic has been determining clinically meaningful change. The current definitions of chan...

OBJECTIVES A persistent infection of enteroviruses and cardioviruses has been implicated in polymyositis and dermatomyositis, but conventional hybridisation studies of the presence of enterovirus RNA and encephalomyocarditis (EMC) virus RNA in affected muscle have yielded conflicting results. To investigate further the possibility of viral persistence, the presence of viral RNA in muscle from p...

Calcinosis is rarely observed in juvenile-onset amyopathic dermatomyositis in contrast to juvenile-onset dermatomyositis. A 6-year-old female presented with several 0.5 to 2 cm-sized painless grouped masses on both knees for 3 years. The patient also presented with multiple erythematous scaly patches and plaques on both elbows, knuckles, buttock, ankles and cheeks. Her mother had similar skin l...