Due to impaired defensive mechanisms caused by injuries or little epithelial defects , different types of pathogens or environmental influences might induce corneal inflammation (keratitis). The form of corneal inflammation called superficial keratitis involves just the corneal surface (epithelium). If the inflammation involves corneal stroma it is called stromal or interstitial keratitis. Kera...

MARINA SOKOVIĆ, JASMINA GLAMOČLIJA, ANA ĆIRIĆ, DRAGAN KATARANOVSKI, PETAR D. MARIN, JELENA VUKOJEVIĆ, DEJAN BRKIĆ University of Belgrade, Mycological laboratotry, Department of Plant Physiology, Institute for Biological Research, “S. Stanković,”, Bulevar despota Stefana 142, Belgrade, Serbia Department of Ecolgy, Institute for Biological Research, “S. Stanković,” University of Belgrade, Bulevar...

Figure 1. Burn wound on post-operative day three after resurfacing with allograft. DESCRIPTION A 54-year-old man sustained third-degree burns to 50% total body surface area. He was transferred to our facility in septic shock on day five after injury. Broad-spectrum antibiotics, burn excision, and resurfacing with allograft were initiated. Two weeks later, a new wound infection was identified (F...

Fungal endophthalmitis is a rare condition often associated with poor prognosis. We present a case of postoperative acute fungal endophthalmitis caused by the yeast-like fungus Stephanoascus ciferrii (Candida ciferrii). The fungus was resistant to fluconazole, voriconazole, and amphotericin B but susceptible to caspofungin. Because the degree of vitreal penetration of caspofungin after its intr...

CONCLUSION Inflammatory diseases, such as non-specific sinusitis, fungal sinusitis and mucocele, commonly involve the sphenoid sinus. Endoscopic surgery provides an easy and successful access to isolated sphenoid sinus diseases (ISSDs) with rare complications. OBJECTIVES The incidence of ISSDs has decreased since a wide use of antibiotics. ISSDs can cause severe complications due to the deep ...

In the past decade, mucormycosis has emerged as an important lethal infection in diabetics and other immunocompromised hosts. Rhinosinusitis, pansinusitis, rhino-orbital and rhinocerebral are the common classical manifestations of mucormycosis. However, primary gastrointestinal (GI) mucormycosis is an uncommon disease associated with a high mortality rate. Stomach is the most common site involv...

The purpose of this investigation was to determine the cytotoxicity of amphotericin B (AMB; trade name Fungizone [FZ]) following the administration of FZ and a heat-treated form of FZ (HFZ) to LLC-PK(1) pig kidney cells and Cryptococcus neoformans var. gattii cells. HFZ was significantly less toxic to kidney cells than FZ at all concentrations tested. For both FZ and HFZ, the concentration rang...

PURPOSE/OBJECTIVES To describe sources of fungal contamination that can incite invasive mycoses in hospitalized and ambulatory neutropenic patients and to discuss approaches to reduce exposure to pathogens. DATA SOURCES Published articles, books, and brochures. DATA SYNTHESIS Modifications of patient environments and lifestyles include hand hygiene for patients and healthcare workers, air f...

Ras p21 proteins have been shown to be posttranslationally farnesylated on a specific carboxyterminal cysteine1 ^. Inhibition of this isoprenylation would alter membrane localization and activation of ras oncogene40. Therefore during our screening for farnesyl-protein transferase (FTase) inhibitors of microbial origin we have isolated gliotoxin (GT) and acetylgliotoxin (AGT) from the fermentati...

Definitive diagnosis of the bat disease white-nose syndrome (WNS) requires histologic analysis to identify the cutaneous erosions caused by the fungal pathogen Pseudogymnoascus [formerly Geomyces] destructans (Pd). Gross visual inspection does not distinguish bats with or without WNS, and no nonlethal, on-site, preliminary screening methods are available for WNS in bats. We demonstrate that lon...