Cutaneous microdialysis is a new tool for direct sampling and real-time monitoring in dermatological research. However, its use in general laboratory practice poses several problems, one of which is determination of the relative recovery of the target material. Uric acid, one of the major antioxidants in the skin, was analysed using cutaneous microdialysis in 11 healthy subjects. Two methods fo...

Methylisothiazolinone (MI), alone or in association with methylchloroisothiazolinone (MCI), is widely used as a preservative in cosmetic and occupational products, and is currently inducing an outbreak of sensitization throughout Europe (1). In the 2000s, MI as stand-alone preservative was introduced in industrial water-based products. Since 2005, several cases of occupational dermatitis caused...

Nail fungal infections are considered one of the major dermatological problems due to their high rate of therapeutic failure, management and treatment difficulties. Long-term treatments, inadequate therapies, mycological misdiagnosis and follow-up, secondary alterations of the nail, and resistant microorganisms, are some of the causes of these complications. Although the discovery of new antifu...

Figure 1. Dermatological lesions.

© 2009 The Society for Investigative Dermatology www.jidonline.org 1313 the formal clinical practice of dermatology in Taiwan was founded more than a century ago. In 1908, a department focusing on skin diseases was established in Taipei Hospital (later known as the National Taiwan University Hospital). In 1913, the chairman of the department, Obo Otohiko, was sent to Germany for 2 years to purs...

Rosacea is a chronic disorder of unknown etiology with facial and ocular manifestations. It frequently affects women in the fourth to seventh decades, and patients often present to ophthalmologists with complaints relating to blepharitis, meibomianitis, or tear disturbances. Characteristic skin change of flushing, erythema, telangiectasis, papules, and pustules should be sought, as patients fre...