Neurofibromatosis type 1, also known as NF1 or von Recklinghausen's disease, is a common neurocutaneous syndrome that presents with multiple café-au-lait patches, skinfold freckling, dermatofibromas, neurofibromas, and Lisch nodules. The mutations of the gene NF1, encoding the protein neurofibromin, have been identified as the cause of this disease. Here, we report a clinical and molecular stud...

Folliculosebaceous cystic hamartoma is a distinctive cutaneous hamartoma composed of follicular, sebaceous, and mesenchymal components. The lesions are most commonly found on the face and scalp of young adults, with approximately 30% occurring in the nasal or paranasal regions of the face. The clinical differential diagnoses are extensive and include epidermoid cyst, dermal nevus, soft fibroma,...

Nowadays, skin cancer is one of the most important problems faced by world, due especially to rapid development cells and excessive exposure UV rays. Therefore, early detection at an stage employing advanced automated systems based on AI algorithms plays a major job in order effectively identifying detecting disease, reducing patient health financial burdens, stopping its spread skin. In this c...

BACKGROUND Dermatofibroma (DF) comprises a heterogeneous group of mesenchymal tumors, with fibroblastic and histiocytic elements present in varying proportions. The cell of origin of DF has been investigated, but remains unclear. OBJECTIVE The present study attempted to investigate the expression of leukocyte-specific protein 1 (LSP1), a marker of fibrocytes, in DF. Additionally, we evaluated...

INTRODUCTION Flap surgeries are an excellent choice for closing large defects following trauma, excision of carcinomas or removal of large lesions. This article is a prospective interventional study of various flap surgeries performed at a tertiary care centre with their outcome in dermatosurgical unit. MATERIALS AND METHODS A total of 35 flap surgeries performed from January 2012 to December...

468 ROBERTO LLAMAS CHEST, 65: 4, APRIL, 1974 deiphia, J B Lippincott Go, 1967, pp 615-620 8 Kepmson RL, Kyriakos M : Fibroxanthosarcoma of the soft tissues : a type of malignant fibrous histiocytoma. Cancer 29:961-976, 1972 9 Fisher ER, Vuzevski VD: Cytogenesis of schwannoma ( neurilemmoma ) neurofibroma, dermatofibroma and dermatofibrosarcoma as revealed by electron microscopy. Am J Clin Patho...

Macroscopic appearances Macule (Fig. 7.1A) A flat, circumscribed lesion; an area of colour or textural change. Macules are seen in vitiligo (hypopigmentation), freckles (hyperpigmentation) and capillary haemangioma (red/purple). Papule (Fig. 7.1B) A solid, circumscribed, palpable elevation of skin less than 5 mm in diameter. They can appear in various forms: e.g. dome shaped (xanthomas), flat t...

A 60-year-old male presented with a solitary, asymptomatic, erythematous annular plaque on the medial portion of his right distal leg. Clinically, the lesion had central atrophy with peripheral hyperpigmentation, elevation and scaling (Figure 1). The differential diagnosis at clinical examination included: granuloma annulare, angular lichen planus, hypertrophic tinea corporis, and pigmented Bow...

A 23-year-old female presented with a reddish-brown dome-shaped hyperkeratotic nodule of 11 × 10 mm on the left lower leg. Dermoscopic examination demonstrated a prominent whitish scaly area with ring-like appearance, pinkish-white structureless areas, a few milia-like cysts, dotted and glomerular vessels, and light brown globules. The lesion was completely excised under the diagnosis of verruc...