Gluten-related disorders are a heterogeneous group of clinical entities caused by intolerance to wheat, rye, and barley flour components. They occur in 3?5% genetically predisposed persons and, based on pathogenic features, classified into celiac disease, non-celiac gluten sensitivity, wheat allergy. There also specific such as dermatitis herpetiformis or ataxia, which can either within the dis...

BACKGROUND Pemphigus herpetiformis (PH) is a rare clinical entity that combines the clinical features of dermatitis herpetiformis and the immunopathologic features of pemphigus. The target antigen is usually desmoglein 1, with exceptional cases manifesting autoantibodies against desmoglein 3. More recently, it has been found that many patients with PH also demonstrate autoantibodies against des...

Sir, Dapsone therapy can cause severe adverse reactions known as the sulphone or dapsone hypersensitivity syndrome (DS). The most common presenting symptom is a maculopapular or exfoliative rash confined to either the upper limbs or the forehead, but it can also be disseminated. The sequence of symptoms – dermatitis, lymphadenopathy notably along the posterior border of the sternomastoid muscle...

Celiac disease is predominantly a disease of the small intestine characterized by chronic malabsorption in genetically susceptible individuals who ingest grains containing gluten, such as wheat, barley, and rye. Although previously believed to be uncommon, celiac disease may be present in up to 1% of the adult and children population. Celiac disease is associated frequently with iron-deficiency...

A 23-year-old woman with a history of interstitial lung disease, positive ANA, and weakly anti-Scl-70 presented periumbilical blisters. Biopsy revealed subepidermal split eosinophils neutrophils suprabasilar acantholysis. Intercellular C3 on direct immunofluorescence (DIF) was suggestive pemphigus vulgaris (PV). She subsequently developed tense vesicle her right shin. Repeat biopsy only demonst...