We have recently reported that long-term memory retention requires synaptic glia for proBDNF uptake and recycling. Through the recycling course, glial cells release endocytic BDNF, a mechanism that is activated in response to glutamate via AMPA and mGluRI/II receptors. Cortical astrocytes express receptors for many different transmitters suggesting for a complex signaling controlling endocytic ...

BACKGROUND Chronic pain is an important medical problem affecting hundreds of millions of people worldwide. Mechanisms underlying the maintenance of chronic pain states are poorly understood but the elucidation of such mechanisms have the potential to reveal novel therapeutics capable of reversing a chronic pain state. We have recently shown that the maintenance of a chronic pain state is depen...

Erratum to ‘‘Rat retinal ganglion cells co-express brain derived neurotrophic factor (BDNF) and its receptor TrkB” [Vision Res. 42 (2) (2002) 151–157] Elena Vecino *, David García-Crespo , Mónica García , Luis Martinez-Millán , Sansar C. Sharma , Eliseo Carrascal b Departamento de Biología Celular e Histología, Facultad de Medicina, Universidad del País Vasco, E-48940 Leioa, Vizcaya, Spain Depa...

BACKGROUND A relationship between bulimia nervosa and reward-related behavior is supported by several lines of evidence. The dopaminergic dysfunctions in the processing of reward-related stimuli have been shown to be modulated by the neurotrophin brain derived neurotrophic factor (BDNF) and the hormone leptin. METHODS Using a randomized, double-blind, placebo-controlled, crossover design, a r...

Disturbances of brain derived neurotrophic factor (BDNF) signalling have been implicated in the evolution of depression, which likely arises, in part, as a result of diminished synaptic plasticity. Predictably, given stressor involvement in depression, BDNF is affected by recent stressors as well as stressors such as neglect experienced in early life. The effects of early life maltreatment in a...

Maternal smoking during pregnancy is associated with a number of adverse offspring outcomes. In the present study, based on 209 offspring from a 3-generation family study of depression, we show that the effects of prenatal exposure on offspring externalizing psychopathology (conduct, substance use disorder) is more pronounced in the presence of lower-expressing brain derived neurotrophic factor...

Brain-derived neurotrophic factor (BDNF) is a neurotrophin that regulates neuronal survival and growth during development. Effects of BDNF on neuronal transmission in the hippocampus, cortex, cerebellum and basal forebrain are important for learning and memory processes [1]. Reduced BDNF may affect synaptic efficiency and connectivity in schizophrenia that is hypothesized to underpin signs and ...

PBS: Phosphate Buffered Saline; CSPG: Chondroitin Sulfate Proteoglycans; ChABC: Chondroitinase ABC; SUR1–TRPM4 : Sulfonylurea Receptor 1–Transient Receptor Potential Melastatin 4, PTEN: Phosphate and Tensin Homolog; mTOR: Mammalian Target of Rapamycin; SOCS3: Suppressor of Cytokine Signaling 3; BDNF: Brain -Derived Neurotrophic Factor; LINGO-1: Leucine Rich Repeat and Ig Domain Containing 1; Tr...

Abbreviations: AMPA: α-amino-hydroxy-5-methyl-isoxazole4-propionate; ATP: Adenosine Triphosphate; BDNF: Brain-Derived Neurotrophic Factor; CNS: Central Nervous System; EAAT: Excitatory Amino-Acid Transporter; FGF: Fibroblast Growth Factor; GDNF: Glial-Derived Neurotrophic Factor; GLAST: Glutamate Aspartate Transporter; GLT-1: Glutamate Transporter-1; NO: Nitric Oxide; IL3: Interleukin-3; IL-6: ...

BDNF plays a critical role in the regulation of synaptic strength and is essential for long-term potentiation, a phenomenon that underlies learning and memory. However, whether BDNF acts in a diffuse manner or is targeted to specific neuronal subcompartments or synaptic sites to affect circuit function remains unknown. Here, using photoactivation of BDNF or syt-IV (a regulator of exocytosis pre...