BACKGROUND Relapse prevention in bipolar disorder can be improved by monitoring symptoms in patients' daily life. Smartphone apps are easy-to-use, low-cost tools that can be used to assess this information. To date, few studies have examined the usefulness of smartphone data for monitoring symptoms in bipolar disorder. OBJECTIVE We present results from a pilot test of a smartphone-based monit...

BACKGROUND Depression screening in primary care yields high numbers. Knowledge of how depressive symptoms change over time is limited, making decisions about type, intensity, frequency and length of treatment and follow-up difficult. This study is aimed to identify depressive symptom trajectories and associated socio-demographic, co-morbidity, health service use and treatment factors to inform ...

This study examines the effects of social ties (with spouse, children, friends, neighbors, other relatives, and community groups) on depressive symptom levels in U.S. and Japanese adults aged 60 and over. Nationally representative survey data from the United States (N = 1,419) and Japan (N = 2,200) indicate that having a spouse, or increased contacts with friends, neighbors and relatives was as...

OBJECTIVE Depression may be a predictor and consequence of obesity. However, available evidence for racial minorities has been inconsistent, and more prospective studies are needed. Thus, this study's objective was to examine whether depressive symptom severity is a predictor and/or consequence of total adiposity over a 9-year period in a representative sample of late middle-aged African-Americ...

Little is currently known about the long-term course of symptom severity and fluctuation in patients with treatment-resistant depression (TRD). We assessed this using the longitudinal interval follow-up evaluation in 115 patients with TRD (84 unipolar, 31 bipolar) with 1-7 years (median 36 months) of follow-up. Of the follow-up months, 39.2% were spent asymptomatic and 21.1% at sub-threshold sy...

OBJECTIVE The aim of this study was to investigate the mediator role of alexithymia and its relationship with childhood traumas (sexual abuse, physical abuse, emotional abuse, emotional neglect, physical neglect) and attachment style (anxiety and avoidance dimensions of attachment) associated depression symptoms in adulthood. METHOD The sample of this study included 417 undergraduate universi...

Meta-analyses of antidepressant treatment in young people have relied exclusively on clinicianrated measures of depressive symptoms. These symptom-based measures may not capture other important correlates of well-being, such as quality of life, functioning, global mental health or well-being, or self-reported depressive symptoms. Results of the present metaanalysis, based on 8 placebo-controlle...

BACKGROUND Growing evidence indicates that anxiety and depressive disorder onset may involve a prodromal buildup of symptoms. Also, stressful life events may precipitate gradual symptom increase, leading to the development of full-blown disorders. This study used prospective longitudinal data to examine the theory that, over time, stressful events, such as parent-adolescent disagreements, influ...

PURPOSE/OBJECTIVES To evaluate gender differences in quality of life (QOL), demographic, clinical, and symptom characteristics.
 DESIGN Prospective, observational.
 SETTING Two radiation oncology departments in northern California.
 SAMPLE 185 patients before initiation of radiation therapy (RT).
 METHODS At their RT simulation visit, patients completed a demographic questionnaire, a me...

AIM The objective of this study was to analyze the changes in depressive and extrapyramidal symptomatology during glycine augmentation of antipsychotic treatment in patients with schizophrenia. MATERIALS AND METHODS Twenty-nine schizophrenic patients (ICD-10) with predominant negative symptoms in stable mental state participated in a 10-week open-label prospective study. Patients received sta...