OBJECTIVE The contribution of visceral fat accumulation to the development of coronary heart disease was previously reported, but the relation between visceral fat accumulation and serum lipoprotein subclasses was unknown. METHODS AND RESULTS We examined the relation of lipoprotein subclasses with visceral fat accumulation in 62 male subjects (aged 22 to 67 years) with visceral fat syndrome o...

KEY FINDINGS Data from the National Health and Nutrition Examination Survey •The prevalence of low high-density lipoprotein (HDL) cholesterol was significantly higher among adults who did not meet recommended physical activity guidelines (21.0%) than adults who met the guidelines (17.7%). •Low HDL cholesterol prevalence differed significantly for both men and women by adherence to physical acti...

Testosterone administration to men is known to decrease high-density lipoprotein cholesterol (HDL-C) and the subclasses HDL(2) and HDL(3). It also might increase the number of small, dense, low-density lipoprotein cholesterol (LDL-C) particles in hypogonadal men. The decrease in HDL-C and in LDL-C size is potentially mediated by hepatic lipase activity, which hydrolyzes lipoprotein phospholipid...

A systematic review and meta-analysis of Mendelian randomization studies using Medline, Cumulative Index to Nursing Allied Health Literature Complete, Scopus databases. Sixteen involving 34,050 patients with an abdominal aortic aneurysm (AAA) 2,205,894 controls were included. Meta-analyses suggested that a 1 standard deviation increase in high-density lipoprotein cholesterol (HDL-C) significant...

Reducing low-density lipoprotein cholesterol (LDL-C) levels does not eliminate cardiovascular risk; most patients obtain only a 25% to 35% risk reduction. When the triglyceride level is above 200 mg/dL, non–high-density lipoprotein cholesterol (non–HDL-C) is a more precise therapeutic target than LDL-C. It can serve as an excellent proxy for assessing the total number of circulating atherogenic...

We ell-trained endurance athletes have average high density lipoprotein cholesterol (HDL-C) concentrations 20 mg/dl or 4050% higher than those of sedentary men.1-3 Triglyceride levels characteristically are 20% lower in these athletes, and low density lipoprotein cholesterol (LDLC) may be 5-10% less.12 Since skeletal muscles neither secrete nor directly catabolize lipoproteins, what links muscu...

OBJECTIVE To test the hypothesis that the progestogen medrogestone has no effect on changes in lipoprotein metabolism evoked by continuous estrogen replacement therapy, paying special attention to high-density lipoproteins (HDL). DESIGN Open multicenter randomized comparative trial. PATIENTS Postmenopausal hysterectomized women aged 49 to 64 years. INTERVENTION Continuous oral treatment w...

The plasma lipoprotein profiles and high density lipoproteins (HDL) were characterized in patients with the genetic disease cerebrotendinous xanthomatosis (CTX). Abnormalities in the HDL may contribute to their increased atherogenesis and excessive deposits of tissue sterols in the presence of low or low-normal concentrations of plasma cholesterol (165 +/- 25 mg/dl) and low density lipoproteins...

High total cholesterol (≥ 240 mg/dL) and low high-density lipoprotein (HDL) cholesterol (< 40 mg/dL) levels are risk factors for cardiovascular disease, the leading cause of U.S. deaths (1–3). From 2007–2008 to 2013–2014, declining trends were observed in high total and low HDL cholesterol prevalence (4). This report provides 2015–2016 estimates for high total and low HDL cholesterol and trends...

The association of habitual physical activity with plasma high-density lipoprotein (HDL) cholesterol and total triglyceride (TG) was examined in 7106 asymptomatic 35-59-year-old white men with primary type II hyperlipoproteinemia who attended the second screening visit of the Lipid Research Clinics Coronary Primary Prevention Trial. Subjects were rated by usual level of physical activity at wor...