Background: Deoxyribozymes (Dzs) can play a role as gene expression inhibitors at mRNA level. Among Dzs, the 10-23 deoxyribozyme has significant potentials for treatment of diseases. Designed Dz includes a catalytic core made of 15 deoxyribonucleotides and two binding arms consisted of 6-12 nucleotides for site specific binding to target RNA and hydrolysis. The enzyme has characteristic feature...

The ability to map plastic deformation around high strain gradient microstructural features is central in studying phenomena such as fatigue and stress corrosion cracking. A method for the visualization of plastic deformation in electron back-scattered diffraction (EBSD) data has been developed and is described in this article. This technique is based on mapping the intragrain misorientation in...

Ultrashort lasers are typically utilized for tissue dissection by sequential application of tightly focused beam along a scanning pattern. Each pulse creates a small (on the order of 1μm) zone of multiphoton ionization (optical breakdown). At energies exceeding vaporization threshold cavitation bubble is formed around the focal volume. A continuous cut is formed if the rupture zones produced by...

[1] We use interferometric synthetic aperture radar (InSAR) to study deformation of the summit caldera at Kīlauea Volcano during 2000–2008, which spanned both an east rift zone eruptive event in 2007 and the start of the ongoing summit eruption in 2008. The data set consists of small baseline subset (SBAS) time series generated from 270 acquisitions on three separate beam modes from the Radarsa...

Mani Earthquake, occurred on Nov. 8, 1997 in Tibet, China, is the strongest event in China since 90’s in 20 century. Investigation and research of its principle and geometry, dynamics related to surface rupture zone is very significant to analyze the development and evolution of China’s earthquake in the future. In this study, we investigate the distribution of surface deformation and extract d...

A hot tear indicator based on the physics of solidification and deformation is presented. This indicator is derived using available data from computer simulation of solidification and solid deformation. Hot tears form when the mushy zone is starved of liquid feeding and deformed in tension. The unfed tensile deformation causes a small additional porosity. A physical model based on a mass balanc...

Density functional theory (DFT) calculations are carried out to study the electronic and magnetic structure of the (001) surface of chromium. Our aim is to identify and characterize the most prominent electronic surface states and make the connection with the main experimental results. We show that a low dispersive minority spin surface state at the center of the surface Brillouin zone plays a ...

Deformation of the ground surface at active volcanoes provides information about magma movements at depth. Improved seafloor deformation measurements between 2011 and 2015 documented a fourfold increase in magma supply and confirmed that Axial Seamount's eruptive behavior is inflation-predictable, probably triggered by a critical level of magmatic pressure. A 2015 eruption was successfully fore...

This paper reports on an experimental study on the ploughing or orthogonal cutting in sand. Plane strain cutting or ploughing experiments were carried out on model Ottawa sand while being imaged at high resolution. The images obtained were further processed using image analysis and the evolution of the velocity and deformation fields were obtained from these analysis. The deformation fields sho...