Grey matter heterotopia are commonly associated with refractory epilepsy. Depth electrodes recordings have shown that epileptiform activity can be generated within these lesions, and also at a distance in the neocortex. Heterotopia seem to be part of a more complex circuitry involving also the surrounding and distant cerebral cortex. Blood oxygenation level-dependent (BOLD) changes to intericta...

The deactivation of triplet excited state riboflavin by polyphenols, e.g. rutin and catechin, was studied on the basis of density functional theory calculations. The results show that the H-atom transfer pathway is more feasible on thermodynamic grounds in comparison with the direct energy transfer or direct electron transfer pathways involved in the triplet excited state riboflavin deactivatio...

Catalyst deactivation causes major losses in the chemical industry worldwide every year [...]

The effective dopant concentration in p-type Si detectors reduces with irradiation fluence at low fluences due to the acceptor removal process, which degrades detector performance and shortens its lifetime. This effect has been experimentally characterized parametrized, but microscopic origin is still unknown. We use atomistic simulations gain insight into neutron by modeling damage generation ...

In the present work, a theoretical study on the deactivation of triplet excited (T(1)) state thioxanthone (TX) by indole (INH) was performed, based on density functional theory calculations. Three feasible pathways, namely direct electron transfer from INH to T(1) state TX, electron transfer followed by proton transfer from INH(.+) to TX(.-), and H-atom transfer from nitrogen of INH to keto oxy...

The homogenous, [IrCp∗I2]2, SCRAM catalyst (1) is active in the racemization of chiral amines. NMR, kinetic and structural mechanistic studies have determined cause deactivation to occur when ammonia or methylamine are liberated by hydrolysis aminolysis intermediate imine, which tightly coordinate iridium centre block turnover. Control moisture substrate concentration can suppress deactivation,...

This article presents predictive modeling of nonlinear guided wave propagation for structural health monitoring using both finite element method and analytical approach. In our study, the nonlinearity of the guided waves is generated by interaction with a nonlinear breathing crack. Two nonlinear finite element method techniques are used to simulate the breathing crack: (a) element activation/de...

Biological cell networks exhibit complex combinations of both discrete and continuous behaviors: indeed, the dynamics that govern the spatial and temporal increase or decrease of protein concentration inside a single cell are continuous diierential equations, while the activation or deactivation of these continuous dynamics are triggered by discrete switches which encode protein concentrations ...

We tested the concept that lesions of primary visual cortical areas 17 and 18 sustained on the day of birth induce a redistribution of cerebral operations underlying the ability to disengage visual attention and then redirect it to a new location. In cats, these operations are normally highly localizable to posterior middle suprasylvian (pMS) cortex. Three stimulation paradigms were used: (i) m...