BACKGROUND Although the global use of the endocrine-disrupting chemical DDT has decreased, its persistence in the environment has resulted in continued human exposure. Accumulating evidence suggests that DDT exposure has long-term adverse effects on development, yet the impact on growth and differentiation of adult stem cells remains unclear. OBJECTIVES Human mesenchymal stem cells (MSCs) exp...

BACKGROUND The organochlorine dichlorodiphenyltrichloroethane (DDT), a known estrogen mimic and endocrine disruptor, has been linked to animal and human disorders. However, the detailed mechanism(s) by which DDT affects cellular physiology remains incompletely defined. OBJECTIVES We and others have shown that DDT activates cell-signaling cascades, culminating in the activation of estrogen rec...

OBJECTIVE Extended-spectrum β-lactamase producing K. pneumoniae is a serious threat to the patients. This manuscript shows the comparison of phenotypic characterization methods used for ESBL K. pneumoniae and frequency distribution of these isolates in various clinical samples. METHODOLOGY Eleven different types of pathological samples collected on various time intervals were analyzed. K. pne...

Microbial degradation of 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) is the most promising way to clean up DDT residues found in the environment. In this paper, a bacterium designated as wax, which was capable of co-metabolizing DDT with other carbon sources, was isolated from a long-term DDT-contaminated soil sample by an enrichment culture technique. The new isolate was identified as ...

Dr. Matteson claims that DDT is associated with reduced lactation. In the United States, where DDT has been banned for 26 years, mothers who stay home breast-feed for an average of 25.1 weeks—mothers who work parttime, for 22.5 weeks (19). In Belize, mothers in urban areas, where DDT is not used for malaria control, breast-feed less than 38.4 weeks—mothers in rural areas with lifetime exposures...

Previous work in our laboratory showed that o,p'-DDT increases the frequency of rat uterine contractions in vitro. The present study investigated whether this response was related to prostaglandin E 2 (PGE2) release from the uterine strips or to the estrogenicity of o,p'-DDT. Contraction frequency was evaluated by recording isometric spontaneous contractions in longitudinal uterine strips from ...

The aim of this study was to investigate the actions of two isomers of DDT (p,p'-DDT, o,p'-DDT) and DDE (p,p'-DDE, o,p'-DDE) on the human placenta. We studied the effects of DDT and its metabolite DDE on CYP1A1 activity and on CYP1A1 and aryl hydrocarbon receptor (AhR) protein expression in placental cells. We used explants from third-trimester human placental tissue and JEG-3 cells, which are ...

SADC announced their intention to produce DDT locally (SADC 2011). Furthermore, the 35 heads of state and government who are members of the African Leaders Malaria Alliance (ALMA) recently endorsed use of DDT in indoor residual spraying (IRS) (ALMA 2010). Such organized actions by affected countries bespeak broad recognition of scientific issues and continuing need for DDT in malaria control pr...