Chromosomal replication is entwined with DNA damage tolerance (DDT) and chromatin structure establishment via elusive mechanisms. Here we examined how specific replication conditions affecting replisome architecture and repriming impact on DDT. We show that Saccharomyces cerevisiae Polα/Primase/Ctf4 mutants, proficient in bulk DNA replication, are defective in recombination-mediated damage-bypa...

Developmental exposure to persistent endocrine disruptors is of a great concern. Affection adrenal hormones production by low-dose dichlorodiphenyltrichloroethane (DDT) has been revealed recently. Objective the research – investigation ultrastructural mechanisms impaired mineralocorticoid and glucocorticoid after prenatal postnatal disruptor DDT. Male Wistar rats exposed low doses DDT during de...

The aim of the presented study was to compare the effect of o,p'-DDT [1,1-dichloro-2,2-bis-(p,p'-chlorophenyl)-ethylene] and p,p'-DDT [1,1,1-trichloro-2,2-bis-(p-chlorophenyl)-ethane] and their metabolites DDE and DDD on estradiol secretion by ovarian follicles, the target organs of environmental estrogens. Theca interna (Tc) and granulosa cells (Gc) were collected from medium size porcine foll...

In 1971, an experiment was conducted in a field containing high amounts of residual DDT (dichlorodiphenyltrichloroethane) to evaluate deep plowing, followed by flooding, with and without organic matter applications, as soil and water management tools to reduce total DDT residues and preferentially degrade the residual DDT to DDD [l,l-dichloro-2,2-bis (p-chlorophenyl) ethane]. The experimental s...

Exemption was granted by the Stockholm Convention in 2004 for use of DDT by indoor residual spraying (IRS) as a malaria vector control. South Africa endorsed the use of DDT in its Malaria Control Programmes in malaria endemic regions and IRS remains a primary method of controlling malaria transmitting mosquitoes in this country. This study examines the impact of IRS on the levels of DDT and its...

Malaria continues to be a public health problem in Bangladesh, despite efforts in the 1960s to eradicate the vectors through the use of DDT. At one point, eradication of malaria was acclaimed but later on it reappeared. The use of DDT is no more legally allowed in Bangladesh, which has been officially replaced by a number organophosphates and/or synthetic pyrethroids and their combinations in a...

Although organochlorine pesticides (OCPs) have been banned for more than three decades, their concentrations only decreased gradually. This may be largely attributable to environmental persistence, illegal application, and exemption usage. study assessed the historic current regional context dichlorodiphenyltrichloroethane (DDT), chlordane, hexachlorobenzene (HCB), which were added Stockholm Co...

susceptibility status of ph.papatasi to ddt 4% has been evaluated in arsanjan country, the new focus of cutaneous leishmaniasis, in fars province in 1999. sandflies were collected from human habitations. tests revealed that this species was sensitive to ddt. results from data analysis showed that lt50 and lt90 can be measured as 30 (fiducially limit; 23, 36) and 55 minutes (fiducially limit: 44...