This review summarizes the mechanisms of the initiator protein DnaA in replication initiation and its regulation in Escherichia coli. The chromosomal origin (oriC) DNA is unwound by the replication initiation complex to allow loading of DnaB helicases and replisome formation. The initiation complex consists of the DnaA protein, DnaA-initiator-associating protein DiaA, integration host factor (I...

I nhaled nitric oxide (NO) has long been known to be an effective pulmonary vasodilator in the normal pulmonary vasculature. In the classical NO signalling pathway, it activates soluble guanylate cyclase in the cytoplasm of pulmonary artery smooth muscle cells, leading to the production of cyclic guanosine monophosphate (cGMP), which then activates protein kinase G (PKG). PKG, acting through se...

To the Editor: We thank Kurtoglu and colleagues for their interest in our article, “Aerobic Exercise Training Decreases Plasma Asymmetric Dimethylarginine Concentrations with Increase in Arterial Compliance in Postmenopausal Women.”1 We demonstrated that 12 weeks of aerobic exercise training decreased plasma asymmetric dimethylarginine (ADMA) concentrations in postmenopausal women. In their Let...