نتایج جستجو برای: dcfh

تعداد نتایج: 390  

2015
X.X. Xie Y.F. Ma Q.S. Wang Z.L. Chen R.R. Liao Y.C. Pan

As an essential trace element, copper can be toxic in mammalian cells when present in excess. Metallothioneins (MTs) are small, cysteine-rich proteins that avidly bind copper and thus play an important role in detoxification. Yeast CUP1 is a member of the MT gene family. The aim of this study was to determine whether yeast CUP1 could bind copper effectively and protect cells against copper stre...

2016
Kai‐Ting Li Qing Chen Da‐Wu Wang Qin‐Qin Duan Si Tian Juan‐Wen He Yun‐Sheng Ou Ding‐Qun Bai

Photodynamic therapy (PDT) is a promising treatment in cancer therapy, with a photosensitizer activated by visible light. Aloe-emodin (AE) is a promising photosensitive agent. In this study, the photosensitizing effects and possible mechanisms of AE-PDT in MG63 cells were evaluated. The efficiency of AE-PDT was analyzed by MTT assay. The mode of cell death was investigated by Hoechst 33,342 sta...

Journal: :Carcinogenesis 2006
George Quievryn Joseph Messer Anatoly Zhitkovich

Recent epidemiological and risk assessment studies have found a very high risk of lung cancer among chromium(VI)-exposed workers even at permissible levels of exposure. However, mechanistic views on the key genotoxic role of transient Cr(V) intermediates were more consistent with the threshold or highly non-linear (heavy dose) models of genetic damage by intracellular Cr(VI). In this work, we e...

2018
Parichaya Aimvijarn Sarawoot Palipoch Seiji Okada Prasit Suwannalert

Melanoma is a cancer that is associated with a high capacity of invasion. Oxidative stress is recognized as cancer growth and progression. The phytochemical pigments of natural products show either anti-oxidant or pro-oxidant activity from the redox system. In addition, the phytophenolics also prevent cancer cell proliferation and progression. Objective: This study aims to investigate the effec...

2017
Ming-Xia Li Yi-Feng Zhao Hai-Xia Qiao Yu-Ping Zhang Xiu-Juan Li Wei-Dong Ren Pei Yu

Chemokines and their receptors play an important role in the pathogenesis of acute and chronic diabetic nephropathy (DN). However, their expression pattern and function in glomerular podocytes have not been investigated as of yet. In the present study, we investigated whether CXCR3 could protect podocytes from high glucoseinduced apoptosis and inflammatory cytokine production and explored the p...

2015
Peihai Zhang Haiqin Yin Sie Wang Yuping Wei Nan Peng Wenxiang Bi Xiaoyuan Wang

INTRODUCTION This study aims to compare the antioxidant abilities of cervical squamous carcinoma cells and cervical adenocarcinoma cells and to study the related mechanisms. MATERIAL AND METHODS Cervical squamous carcinoma and adenocarcinoma cells were treated with H2O2. Cell proliferation was determined with the MTT assay. The reactive oxygen species (ROS) level was detected by the 2',7'-dic...

2014
Yongsheng Li Na Han Tiejun Yin Lulu Huang Shunfang Liu Dongbo Liu Cuihong Xie Mengxian Zhang

Radioresistance remains a significant therapeutic obstacle in glioblastoma. Reactive oxygen species (ROS) are associated with multiple cellular functions such as cell proliferation and apoptosis. Nox4 NADPH oxidase is abundantly expressed and has proven to be a major source of ROS production in glioblastoma. Here we investigated the effects of Nox4 on GBM tumor cell invasion, angiogenesis, and ...

2014
Rong Guo Weiming Li Baoxin Liu Shuang Li Buchun Zhang Yawei Xu

BACKGROUND Resveratrol exhibits beneficial effects against numerous degenerative diseases at different stages of pathogenesis. This study investigated potential mechanisms and resveratrol effects on high glucose (HG)-induced oxidative stress (30 mM D-glucose, 30 min) and cell proliferation (30 mM D-glucose, 24 h) in vascular smooth muscle cells (VSMCs). MATERIAL/METHODS Intracellular reactive...

Journal: :Annals of hepatology 2007
Francesco Marotta Masatoshi Harada Khean-Lee Goh Aldo Lorenzetti Paolo Marandola Emilio Minelli

HepG2 human hepatoma cells were incubated for 24 or 48 h with various concentrations of YHK solution. After 24 h incubation, cell proliferation and cytotoxicity were determined by 3-(4,5-dimethylthiazol-2- yl)-5-(3- carboxymethoxyphenyl)-2-(4-sulfophenyl)-2Htetrazolium (MTT) assay. Cytotoxicity or necrosis was expressed as lactate dehydrogenase (LDH) release. After exponential growth phase HepG...

2017
Hyun Ah Lee Bo Ram Song Hye Ryeong Kim Ji Eun Kim Woo Bin Yun Jin Ju Park Mi Lim Lee Jun Young Choi Hee Seob Lee Dae Youn Hwang

Roots of Asparagus cochinchinesis have been widely used to treat fever, cough, kidney disease, breast cancer, inflammatory and brain disease, although the effects of their fermented products have not been assessed until now. To investigate the anti-inflammatory effects on macrophages of a butanol extract from A. cochinchinensis roots fermented with Weissella cibaria (BAW), alterations in the in...

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