Background: DNA damage is one of the major consequences of radiation exposure onto the biological systems. A series of compounds including flavanoids were found to render DNA protection against radiation damage. In this study we elucidated the potential of rutin and rutin hydrate to protect plasmid DNA against damage induced by irradiation. Materials and Methods: DPPH and hydroxyl radical scave...

Abstract: Modal analysis is a powerful technique for understanding the behavior and performance of structures. Modal analysis can be conducted via artificial excitation, e.g. shaker or instrument hammer excitation. Input force and output responses are measured. That is normally referred to as experimental modal analysis (EMA). EMA consists of three steps: data acquisition, system identificatio...

Indentation tests were used for early detection of deformation-induced damage Inconel 718. Damage was produced in a controlled manner using specially designed specimens with variable width the gage part. Static tension, LCF, and HCF performed to induce material damage. Accumulated plastic strain intensity as reference measure Detection progress its phase based on use strain-hardening cross-effe...

This paper presents a structural parameter estimation technique for finite element model updating for the bridge benchmark model at the University of Central Florida (UCF) and the anticipated nondestructive tests. The purpose of the benchmark problem is to evaluate the reliability of damage assessment methodologies commonly used in structural health monitoring of the highway bridges. Simulation...

Impact problems are typical in nature since they involve geometry, boundary and material non-linearity. The impact of projectiles at sub-ordnance velocities against mild steel, stainless steel and aluminum plates has been studied. In this paper, target plates of 3mm thickness of materials Mild steel, Titanium are made to impact by Tungsten fragment with different velocities 300, 500, 700 and 10...

In the present paper the damage of fiber-reinforced polymeric matrix laminates is considered with the aim to examine their mechanical properties. The damage mode in the form of intralaminar cracks (“primary matrix cracking”) is described in terms of second order, symmetrical damage tensor by Vakulenko and Kachanov. It allows for considering the orientation of the defects, which is determined by...

A model is presented to investigate the optimal economic life cycle of grass leys with winter damage problems in northern Norway and to determine the threshold of winter damage before it is profitable to reseed. A two-level hierarchic Markov process has been constructed using the MLHMP software. The model takes uncertainty concerning yield potential, damage estimation and weather dependent rand...

We used flow cytometry to analyze the cell cycle, DNA damage, and apoptosis in hematopoietic subsets in MDS marrow. Subsets were assigned using CD45, side scatter, CD34, and CD71. Cell cycle fractions were analyzed using DRAQ 5 (DNA content) and MPM-2 (mitoses). DNA damage was assessed using p-H2A.X, and apoptosis using Annexin V. Compared to controls, MDS patients demonstrated no increased mit...

This paper presents comparative assessment of the performance characteristics of two optimization algorithms, namely a deterministic nonlinear least squares (NLS) optimization and a stochastic adaptive simulated (ASA) annealing global optimization, implemented in the context of a two-stage structural damage severity estimation approach. First, both the standard NLS and global ASA optimization a...

Cryogenic cooling of macromolecular crystals is commonly used for X-ray data collection both to reduce crystal damage from radiation and to gather functional information by cryogenically trapping intermediates. However, the cooling process can damage the crystals. Limiting cooling-induced crystal damage often requires cryoprotection strategies, which can involve substantial screening of solutio...