Abstract Wideband hybrid frequency synthesizer with phase-locked loop (PLL) and high-speed direct-to-analog converter (DAC) is presented. The use of special DAC operating modes allows to expand the generating band. Presented also provides a low phase noise due using RF mixer in PLL feedback.

Techniques are proposed to dramatically reduce the impact of quantization noise in fractional-N synthesizers, thereby improving the existing tradeoff between phase noise and bandwidth that exists in these systems. The key innovation is the introduction of new techniques to overcome nonidealities in a phase-frequency detector (PFD)/digital-to-analog converter (DAC) structure, which combines the ...

BACKGROUND The reliability of patient-reported penicillin allergies has been disputed. A Drug Allergy Clinic (DAC) was established at our institution in combination with an electronic best practice alert (BPA) in the Orthopedic Clinic. Joint arthroplasty patients with a reported history of beta-lactam allergy (HOBA) were preoperatively referred via the BPA to the DAC. The purpose of this study ...

Freed, Arthur N., Varsha Taskar, Brian Schofield, and Chiharu Omori. Hyperventilation-induced airway injury and vascular leakage in dogs: effects of a1-adrenergic agonists. J. Appl. Physiol. 83(6): 1884–1889, 1997.—a1Adrenergic agonists inhibit hyperventilation-induced bronchoconstriction (HIB) in dogs. We tested the hypothesis that a-agonists inhibit HIB by reducing bronchovascular leakage and...

Two opposed high-quality diamonds pressing against a sample constrained by a metallic foil, acting as a deforming gasket, constitute the core of the diamond anvil high pressure cell or DAC for short. Notwithstanding its relatively small size, a DAC can generate pressures exceeding that prevailing at the core of the Earth, i.e., above 360 GPa (100 GPa = 1 Mbar). The good transmissivity of the di...

ARHI is a maternally imprinted tumor suppressor gene that is expressed in normal breast epithelial cells but not in most breast cancer cells. Aberrant methylation and hypernomic histone deacetylation have been implicated in the silencing of ARHI. To investigate the mechanism of ARHI induction, MDA-MB-231 breast cancer cells were either transfected with the eukaryotic expression vector, pcDNA3.1...

El objetivo de este trabajo fue evaluar el enraizamiento estacas Croton urucurana Baill., Tabernaemontana catharinensis A. DC. y Paullinia elegans Cambess conocidas en Argentina como “Sangre drago” (SD), “Horquetero” (TC) “Ojo muñeca” (PE), respectivamente. Se recolectaron 200 leñosas por especie; una vez defoliadas se aplicó ácido naftalén acético (ANA) las siguientes dosis: 0, 1000, 2500 3500...

Myelodysplastic syndromes and chronic myelomonocytic leukemia (CMML) are characterized by mutations in genes encoding epigenetic modifiers and aberrant DNA methylation. DNA methyltransferase inhibitors (DMTis) are used to treat these disorders, but response is highly variable, with few means to predict which patients will benefit. Here, we examined baseline differences in mutations, DNA methyla...

Spatial distributions find applications in various fields, such as public health, biology, ecology, geography, economics or sociology. The DAC statistic is the difference between the empirical cumulative distribution of cases and that of non-cases at a particular point. Simulations indicated that the location of the maximum DAC statistic is not unique. Previous studies attempting to use the DAC...

In combination with a single-crystal diamond anvil cell (DAC), a polycapillary half-lens (PHL) re-focusing optics has been used to perform high-pressure extended X-ray absorption fine-structure measurements. It is found that a large divergent X-ray beam induced by the PHL leads the Bragg glitches from single-crystal diamond to be broadened significantly and the intensity of the glitches to be r...