T helper cells are crucial for psoriasis pathogenesis. Communication between and psoriatic keratinocytes (KCs) helps drive the Th1 Th17 response, but underlying mechanism is not well-understood. Small extracellular vesicles (sEVs) emerging mediators of intercellular communication. Here, we investigated role KC-derived sEVs in response psoriasis. We isolated characterized from KCs under normal (...