Active transport of conjugated bile salts, Na-tauro- and Na-glycocholate and D-galactose, was examined in the small intestine of streptozotocin-diabetic rats by an in-vitro technique. Tissue uptake and mucosal to serosal transport of conjugated bile salts and D-galactose was enhanced in diabetic rat ileum. The minimal transport capacity for conjugated bile salts in the jejunum did not differ be...

teins on the tumor cells was shown to be specific, pH de pendent, and concentration dependent. Native ricin, abrin, D-galactose, and its sterically related saccharides inhibit this specific binding, while concanavalin A, bovine serum albumin, heat-denatured abrin or ricin, and other sac charides do not. In the presence of D-galactose, the inhibi tion of protein biosynthesis by ricin does not oc...

The selective oxidation of the 6-hydroxy group of D-glucose to introduce an aldehyde functionality is not catalyzed by known oxidase enzymes. Selective functionalization at the glucose C-6 position in oligoand polysaccharides is a synthetically useful reaction that would greatly facilitate further chemical modifications for food, pharmaceutical, and materials applications. We chose the fungal e...

Inactivation of purified β-Galactosidase was done with GdnHCl in the absence and presence of varying [galactose] at 50°C and at pH 4.5. Lineweaver-Burk plots of initial velocity data, in the presence and absence of guanidine hydrochloride (GdnHCl) and galactose, were used to determine the relevant K(m) and V(max) values, with p-nitrophenyl β-D-galactopyranoside (pNPG) as substrate, S. Plots of ...

OBJECTIVE(S) In the current study, the effects of selected folk medicinal herbs were evaluated in D-galactose-induced aging in male mice. MATERIALS AND METHODS Male BALB/c mice were randomly divided into 12 groups composing sham, control, and treated groups. Aging was induced by administration of D-galactose (500 mg/kg/day for 6 weeks). A positive control group was assigned that received vita...

Trypanosoma cruzi, the agent of American trypanosomiasis is unable to synthesize sialic acid (SA). Instead of using the corresponding nucleotide sugar as donor of the monosaccharide, the transfer occurs from alpha-2,3-linked SA in the host sialoglycoconjugates to terminal beta-galactopyranosyl units of the parasite mucins. For that purpose, T. cruzi expresses a glycosylphosphatidylinositol-anch...