نتایج جستجو برای: cytotoxicity activity

تعداد نتایج: 1164261  

Objective(s): Nepeta binaludensis Jamzad (Lamiaceae) has been used in folk medicine of Iran to cure various diseases. The plant is an endemic species to the country that has recently been identified in Razavi Khorasan province. To evaluate the antioxidant and anti-melanogenesis of N. binaludensis, in this study the inhibitory activity of different extracts of N. binaludensis in murine melanoma ...

Araz Ostadi Hassan Malekinejad, Johanna Fink-Gremmels, Nazli Alizadeh-Tabrizi

The pathogenesis of equine grass sickness (EGS) has not fully understood. A better understanding of the exact pathogenesis of diseases can help to make an accurate diagnosis. Previous studies reported some pathological damage of neuronal cells in EGS patients. In this study, primarily cytotoxicity of serum from three clinically EGS-diagnosed horses on PC12 Tet-off (PTO) cells was assessed. Subs...

Lipid nanocapsules (LNCs) represent a stable, biocompatible and worthwhile drug delivery system, demonstrating significant potential as gene/drug delivery platforms for cancer therapy. Imatinib, a potent tyrosine kinase inhibitor, has revolutionized the therapy of malignancies resulting from abnormal tyrosine kinase activity. However, its Clinical effectiveness in cancer treatment is h...

Lipid nanocapsules (LNCs) represent a stable, biocompatible and worthwhile drug delivery system, demonstrating significant potential as gene/drug delivery platforms for cancer therapy. Imatinib, a potent tyrosine kinase inhibitor, has revolutionized the therapy of malignancies resulting from abnormal tyrosine kinase activity. However, its Clinical effectiveness in cancer treatment is h...

Journal: :Asian Pacific journal of tropical biomedicine 2013
Kwan Yuet Ping Ibrahim Darah Yeng Chen Sreenivasan Sasidharan

OBJECTIVE To evaluate the cytotoxicity and genotoxicity activity of Euphorbia hirta (E. hirta) in MCF-7 cell line model using comet assay. METHODS The cytotoxicity of E. hirta extract was investigated by employing brine shrimp lethality assay and the genotoxicity of E. hirta was assessed by using Comet assay. RESULTS Both toxicity tests exhibited significant toxicity result. In the comet as...

2015
Bing Xu Fuhao Chu Yuzhong Zhang Xiaobo Wang Qiang Li Wei Liu Xin Xu Yanyi Xing Jing Chen Penglong Wang Haimin Lei Bing Yan

A series of novel ligustrazine-triterpenes derivatives was designed, synthesized and screened for their cytotoxicity against five cancer cell lines (Bel-7402, HepG2, HT-29, Hela, and MCF-7) and Madin-Darby canine kidney (MDCK). Current study suggested that most of the ligustrazine-triterpenes conjunctions showed better cytotoxicity than the starting materials. In particular, compound 4a exhibit...

2014
Paul G. Wahome Kevin R. Beauchesne Anna C. Pedone John Cavanagh Christian Melander Paul Zimba Peter D. R. Moeller

Aquatic microbes produce diverse secondary metabolites with interesting biological activities. Cytotoxic metabolites have the potential to become lead compounds or drugs for cancer treatment. Many cytotoxic compounds, however, show undesirable toxicity at higher concentrations. Such undesirable activity may be reduced or eliminated by using lower doses of the cytotoxic compound in combination w...

Journal: :iranian biomedical journal 0
مهدی صابری mehdi saberi علی زارعی محمودآبادی ali zaree mahmodabady

background: using human skin-fibroblast cell line hf2ff, the efficacy of some drugs was evaluated against sulfur mustard (sm) cytotoxicity. the drugs were the sulfhydryl containing molecule including n-acetylcysteine (nac), 2-oxo-thiazolidine-4-carboxylate (otc) and acetaminophen as glutathione (gsh) stimulator pathway. methods: the protective effects of nac (0.1 mm), otc (1.8 mm), and acetamin...

Journal: :Oral 2021

In recent years, calcium silicate cements have been introduced. The purpose of this study is to analyze the main differences between silicate-based and epoxy resin-based cements, analyzing scientific literature last year highlight advantages for predictable clinical use. Data collected from included studies were used in order different features: chemical-physical properties, cytotoxicity cell m...

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