few studies have been conducted on the causative factors associated with the development of cancer. infection by high risk human papillomaviruses (hpvs) have been implicated as causative agents in a variety of cancers. hpv is capable of evading immune system and establishing persistent infections. prolonged infection and lesion maintenance are associated with higher risk of neoplastic progressi...

the medicinal plants have been used since ancient times and are still utilized by the majority of the population. hence, it is essential to investigate the cytotoxic and genotoxic effects of these plants. the aim of this study was to evaluate the toxic effects of fennel seeds decoctions, traditionally used in iran as an herbal remedy.  the cytotoxicity was tested in vitro using allium cepa l. r...

conclusions as l. crispatus and l. jensenni were significantly higher in bv infected women and the cytotoxic effect of l. crispatus on tumoral cervical cells was high, introduction of new probiotics seems necessary. results l. crispatus, l. gasseri, l. iners, l. jensenii, l. acidophilus and l. rhamnosus were the most frequently occurring species in vagina of healthy iranian women. l. crispatus ...

Cytomegalovirus (CMV) infection is one of the most common persistent viral infections in humans worldwide and is epidemiologically associated with many adverse health consequences during aging. Previous studies yielded conflicting results regarding whether large, CMV-specific T-cell expansions maintain their function during human aging. In the current study, we examined the in vitro CMV-pp65-re...

Antibodies (Abs) that preferentially target oncogenic receptors have been increasingly used for cancer therapy, but tumors often acquire intrinsic Ab resistance after prolonged and costly treatment. Herein we armed the Ab with IFNβ and observed that it is more potent than the first generation of Ab for controlling Ab-resistant tumors. This strategy controls Ab resistance by rebridging suppresse...