نتایج جستجو برای: cytomegalovirus
تعداد نتایج: 19396 فیلتر نتایج به سال:
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Prevalence of antibodies to CMV in the female population of Rawalpindi and Islambad was determined. Twenty six percent children under 2 years of age showed antibodies to CMV increasing to 61% by adolescence. Over 90% of adult and pregnant females were sero positive. Association of development of CMV antibodies to socio-economic conditions and different geographical regions is also discussed. Ne...
A total of 2,718 blood samples were analyzed in five virological laboratories for the presence of cytomegalovirus (CMV) by in-house tests and one standardized plasma PCR assay. Results from in-house tests showed remarkable variability. Detection of CMV pp65 antigen or DNA from cells was more sensitive than that by plasma CMV PCR assay.
Live attenuated strains of human cytomegalovirus are under development as vaccines to prevent birth defects resulting from congenital infections. These strains encode four proteins that inhibit surface expression of MHC class I, presumably to evade cytotoxic T-cell recognition and, perhaps, attenuate induction of immunity. To initiate studies of the role of class I down-regulation on congenital...
We conducted a cross-sectional study of beta-herpesviruses in febrile pediatric oncology patients (n = 30), with a reference group of febrile pediatric solid-organ transplant recipients (n = 9). One (3.3%) of 30 cancer patients and 3 (33%) of 9 organ recipients were PCR positive for cytomegalovirus. Four (13%) of 30 cancer patients and 3 (33%) of 9 transplant recipients had human herpesvirus 6B...
congenital cytomegalovirus infection. J. Infect. Dis. 209, 1573–1584. doi:10.1093/ infdis/jiu019 31. Williams, E.J. et al. (2013) Viral infections: contributions to late fetal death, stillbirth, and infant death. J. Pediatr. 163, 424–428. doi:10.1016/j.jpeds.2013. 02.004 32. Lorenzoni, F. et al. (2014) Neonatal screening for congenital cytomegalovirus infection in preterm and small for gestatio...
We evaluated serial enzyme and bilirubin determinations as aids to diagnosis of Epstein-Barr virus-induced infectious mononucleosis (121 cases) and the heterophil-negative mononucleosis-like illness due to cytomegalovirus (33 cases). Laboratory evidence for either type of mononucleosis includes mild to moderate hepatic dysfunction, with aspartate aminotransferase activity increased, but lower t...
We report a pediatric patient admitted with abdominal pain, diffuse lower extremity edema and watery diarrhea for two months. Laboratory findings including complete blood count, serum albumin, lipid and immunoglobulin levels were compatible with protein losing enteropathy. Colonoscopic examination revealed diffuse ulcers with smooth raised edge (like "punched out holes") in the colon and termin...
BACKGROUND Cytomegalovirus end-organ disease can be prevented by giving ganciclovir when viraemia is detected in allograft recipients. Values of viral load correlate with development of end-organ disease and are moderated by pre-existing natural immunity. Our aim was to determine whether vaccine-induced immunity could do likewise. METHODS We undertook a phase-2 randomised placebo controlled t...
Human cytomegalovirus has previously been shown to induce the accumulation of cyclooxygenase-2 RNA, protein, and enzyme activity. High doses of cyclooxygenase inhibitors substantially block viral replication in cultured fibroblasts. However, doses corresponding to the level of drug achieved in the plasma of patients have little effect on the replication of human cytomegalovirus in cultured cell...
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