نتایج جستجو برای: cytochrome c release

تعداد نتایج: 1268317  

Journal: :Biochemical Society transactions 2002
Erich Gnaiger A V Kuznetsov

In the intracellular microenvironment of active muscle tissue, high rates of respiration are maintained at near-limiting oxygen concentrations. The respiration of isolated heart mitochondria is a hyperbolic function of oxygen concentration and half-maximal rates were obtained at 0.4 and 0.7 microM O(2) with substrates for the respiratory chain (succinate) and cytochrome c oxidase [N,N,N,N',N'-t...

Journal: :The Journal of Cell Biology 1999
Solange Desagher Astrid Osen-Sand Anthony Nichols Robert Eskes Sylvie Montessuit Sandra Lauper Kinsey Maundrell Bruno Antonsson Jean-Claude Martinou

Here we report that in staurosporine-induced apoptosis of HeLa cells, Bid, a BH3 domain containing protein, translocates from the cytosol to mitochondria. This event is associated with a change in conformation of Bax which leads to the unmasking of its NH2-terminal domain and is accompanied by the release of cytochrome c from mitochondria. A similar finding is reported for cerebellar granule ce...

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