The syndrome of sea-blue histiocyte, hepatic porphyria, and infectious mononucleosis occurring simultaneously in a young girl is described. The cytochemical staining character of the bone marrow histiocytes strongly suggested that the storage material was glycolipid. The possible relationship between the multiple disorders in the same patient is discussed.

This study characterizes the cytochemical properties of the Golgi complex, the structure which corresponds to Golgi complex-endoplasmic reticulum-lysosomes (GERL), and the granule population in luteal cells of guinea pigs at the time of maximum progesterone secretion, in material fixed by vascular perfusion, a method particularly suited for preserving both fine structure and enzyme activity. Th...

IN studying the distribution in tissues of substances which react with reduced fuchsin, it is frequently necessary to distinguish between (a) substances which react as though they were free aldehydes; (A) substances which react as though they were aldehyde acetals; and (c) substances which react as aldehydes as a result of oxidation of precursors in the tissue. In a recent paper on the plasmal ...

Initially polypeptide hormones were assayed by their biological activity. Such conventional bioassays, however, are remarkably insensitive. For example, the Lipscomb and Nelson (1962) bioassay of corticotrophin (ACTH) cannot measure a concentration of less than about 100 pg/ml, while the normal circulating levels of the bioactive form of this hormone range from about 5 to 60 pg/ml. The introduc...