نتایج جستجو برای: cyproterone acetate

تعداد نتایج: 50084  

Journal: :Molecular endocrinology 2004
Liang-Nian Song Meghan Coghlan Edward P Gelmann

Mifepristone is a potent antagonist of steroid hormone receptors such as glucocorticoid and progesterone receptors. We investigated the potential for mifepristone to act as an antiandrogen and compared it with partial androgen receptor (AR) agonists and antagonists, in particular bicalutamide. Mifepristone was an effective antiandrogen in vitro that inhibited transcription from three androgen-r...

Journal: :Molecular endocrinology 1992
D A Wolf P Schulz F Fittler

Using gene-specific synthetic oligonucleotides the expression and regulation of kallikrein-like genes in the human prostatic cancer cell line LNCaP were studied. Prostate-specific antigen (PSA) and human glandular kallikrein (hGK-1) together constitute a subfamily of serine proteases exclusively produced in the human prostate. RNA analysis revealed that both genes are expressed in LNCaP cells w...

Journal: :Molecular human reproduction 1998
I Woolveridge A A Bryden M F Taylor N J George F C Wu I D Morris

Apoptosis and its augmentation by androgen withdrawal is an important event in the testis. In other tissues apoptosis is regulated by genes belonging to the bcl-2 family. However, little is known about these pathways in the human testes. Human testes were obtained from patients with prostate cancer, undergoing orchidectomy for permanent androgen ablative treatment. The patients were either untr...

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