Tumor cell resistance to apoptosis, which is triggered by many anti-tumor therapies, remains a major clinical problem. Therefore, development of more efficient therapies is a priority to improve cancer prognosis. We have previously shown that a cell-permeable peptide derived from the p120 Ras GTPase-activating protein (RasGAP), called TAT-RasGAP317-326, bears anti-malignant activities in vitro ...

, 399 (2009); 326 Science et al. Karl J. Friston, Neuroimaging Modalities, Modes, and Models in Functional www.sciencemag.org (this information is current as of October 16, 2009 ): The following resources related to this article are available online at http://www.sciencemag.org/cgi/content/full/326/5951/399 version of this article at: including high-resolution figures, can be found in the onlin...

OBJECTIVE This study was undertaken to determine the ability of history taking alone, compared with pregnancy testing, to identify early pregnancies among potential female measles vaccinees. METHODS As part of an institution-wide measles immunization program, 326 female health care workers (HCWs) who denied being pregnant underwent a urine pregnancy test prior to vaccination. RESULTS Of the...

this comment is to show that theorem3.3 of dey and chung (1991) (multiparameter estimation intruncated power series distributions under the stein's loss.emph{commun. statist.-theory meth.,} {bf 20}, 309-326) may giveus misleading results. analytically and through simulation, weshow that the theorem does not improve the given estimator.

Antibiotic resistance has become a major health issue. Nosocomial infections and the prevalence of resistant pathogenic bacterial strains are rising steadily. Therefore, there is an urgent need to develop new classes of antibiotics effective on multi-resistant nosocomial pathogenic bacteria. We have previously shown that a cell-permeable peptide derived from the p120 Ras GTPase-activating prote...

Although current anti-cancer protocols are reasonably effective, treatment-associated long-term side effects, induced by lack of specificity of the anti-cancer procedures, remain a challenging problem in pediatric oncology. TAT-RasGAP317-326 is a RasGAP-derived cell-permeable peptide that acts as a sensitizer to various anti-cancer treatments in adult tumor cells. In the present study, we asses...