نتایج جستجو برای: cypa
تعداد نتایج: 264 فیلتر نتایج به سال:
The NS5A protein of hepatitis C virus (HCV) plays roles in both virus genome replication and the assembly of infectious virus particles. NS5A comprises three domains, separated by low-complexity sequences. Whilst the function of domain I appears to be predominantly involved with genome replication, the roles of domains II and III are less well defined. It has been reported previously that a del...
From a cDNA library, constructed from mushroom primordia, nine cDNAs were isolated which were either induced or specifically expressed during fruit body development and maturation of the basidiomycete Agaricus bisporus. These cDNAs varied in size from 372 to 1019 bp and hybridized to transcripts of 400-1600 nt. Four of the cDNAs were only expressed in the generative phase of the life cycle whil...
So far, we still lack a clear molecular mechanism to explain the protein-ligand interaction on the basis of electronic structure of a protein. By combining the calculation of the full electronic structure of a protein along with its hydrophobic pocket and the perturbation theory, we found out two rules on the protein-ligand interaction. One rule is that the interaction only occurs between the l...
آفلاتوکسین ها یک گروه پلی کتاید مشتق از فورانوکومارین ها هستند که توسط تعدادی از گونه های آسپرژیلوس تولید می شوند. در تحقیق حاضر اثر ممانعت کنندگی کورکومین، کوئرستین، اوگنول و لوتئولین بر رشد قارچ و در تولید آفلاتوکسین در آسپرژیلوس فلاووس با تاکید بر بیان ژنهای aflr, ver1,nor1, nada و cypa مورد بررسی قرار گرفت. اسپور های آسپرژیلوس فلاووس بوسیله روش tip culture در محیط کشت عصاره مخمر- سوکروز حاو...
Cyclophilin inhibitors currently in clinical trials for hepatitis C virus (HCV) are all analogues of cyclosporine (CsA). Sanglifehrins are a group of naturally occurring cyclophilin binding polyketides that are structurally distinct from the cyclosporines and are produced by a microorganism amenable to biosynthetic engineering for lead optimization and large-scale production by fermentation. Pr...
Cyclophilins (CyPs) are a widespreading protein family in living organisms and possess the activity of peptidyl-prolyl cis-trans isomerase (PPIase), which is inhibited by cyclosporin A (CsA). The human nuclear cyclophilin (hCyP33) is the first protein which was found to contain two RNA binding domains at the amino-terminus and a PPIase domain at the carboxyl-terminus. We isolated the hCyP33 gen...
Cyclosporin A (CsA) is a widely used immunosuppressant drug. Its immunosuppressive activity occurs through the inhibition of the protein phosphatase calcineurin via formation of a ternary complex with cyclophilin A (CypA). CsA also inhibits endothelial cell proliferation and angiogenesis. This has been thought to occur through calcineurin inhibition as well. However, CsA is also a potent inhibi...
The primate TRIM5 proteins constitute a class of restriction factors that prevent host cell infection by retroviruses from different species. The TRIM5 proteins act early after virion entry and prevent viral reverse transcription products from accumulating. We recently found that proteasome inhibitors altered the rhesus monkey TRIM5alpha restriction of human immunodeficiency virus type 1 (HIV-1...
The occurrence of neutrophils at the pannus-cartilage border is an important phenomenon for understanding the pathogenesis of rheumatoid arthritis (RA). Matrix metalloproteinases (MMPs) are predominant enzymes responsible for the cartilage degradation. The present article studied the expression of CD147 on neutrophils and its potential role in neutrophil chemotaxis, MMPs production and the inva...
Aspergillus Xavus populations are genetically diverse. Isolates that produce either, neither, or both aXatoxins and cyclopiazonic acid (CPA) are present in the Weld. We investigated defects in the aXatoxin gene cluster in 38 nonaXatoxigenic A. Xavus isolates collected from southern United States. PCR assays using aXatoxin-gene-speciWc primers grouped these isolates into eight (A–H) deletion pat...
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