Gebelikte D vitamini homeostazını etkileyen birçok faktör vardır. Özellikle gebeliğin ikinci ve son trimesterinde fetüsün kemik gelişimine bağlı olarak gereksinimi artmaktadır. Son yıllarda vitamininin gelişimi dışındaki etkilerinin ortaya çıkması fetal programlamada etkili olması nedeniyle, güncel bir konu haline gelmiştir. prekonsepsiyonel dönemden itibaren hem maternal de hastalıkların patog...

The vitamin D receptor (VDR) serves as a for active hydroxyderivatives. formation of hydroxyderivatives requires the presence specific cytochrome P450 (CYP) enzymes metabolism. These can be further hydroxylated by CYP27B1 at C1α-position which increases their affinity VDR. However, role in antiproliferative and antifibrotic activities CYP11A1-derived D3-metabolites is unknown. We tested action ...

Background: Uncertainty exists about the impact of placental vit D metabolism on mother's blood levels in people. Objective: Awareness and how it affects amount metabolites was one goals this investigation. Methods: To take part a 14-week controlled feeding experiment, 27 third-trimester singleton pregnant women good health from Hayatabad Medical Complex during Jan 2022 to April 2022. Female tr...