INTRODUCTION Sebaceous hyperplasia is associated with immunosuppressive treatment with cyclosporin in male renal transplant patients. This has not been reported in the local context. CLINICAL PICTURE This is a report on 2 Chinese renal transplant patients on cyclosporin who developed sebaceous hyperplasia. TREATMENT AND OUTCOME One patient was treated with carbon dioxide laser. The result w...

PURPOSE Overexpression of the multidrug resistance proteins P-glycoprotein (Pgp), multidrug resistance protein (MRP-1), breast cancer resistance protein (BCRP), and lung resistance protein (LRP) is associated with treatment failure in acute myeloid leukemia (AML) and other malignancies. The Pgp modulator cyclosporin A has shown clinical efficacy in AML, whereas its analogue PSC-833 has not. Cyc...

Recently there has been a resurgence of interest in cyclic peptides due to their therapeutic advantages in terms of potency, permeability, proteolytic stability, and unique selectivity relative to traditional smaller drug molecules. Cyclosporin is a family of cyclic peptides widely used as autoimmune suppression agents. Cyclosporin analogs consist of eleven amino acids with the main difference ...

We have studied the effect of the immunosuppressive agent cyclosporin on collagen induced arthritis in mice. Cyclosporin, when given prophylactically, was capable of suppressing the development of collagen induced arthritis and the immunological response to native type II collagen in a dose dependent manner. Furthermore, treatment with cyclosporin, started on the same day as the booster injecti...

Cyclosporin 5, 10, and 20 mg/kg bw was given to rats once daily intragastrically and caused a dose dependent, significant decrease of glucose dependent insulin release from the arterially perfused isolated pancreas, without affecting animal behaviour, weight gain, microscopic appearances of the pancreas, or kidney function. Subcutaneous injection of a new synthetic prostaglandin analogue Riopro...

NK cell cytolytic activity is enhanced after exposure to IFN and/or IFN inducers in vitro (1, 2) and in vivo (3-6). In vitro, IFN induces NK cell cytotoxicity on a per cell basis (1, 2) . In vivo, IFN not only enhances the level of killing mediated by individual cells, but also induces the blastogenesis and proliferation of NK cells (3-6). NK cell blastogenesis is observed during viral infectio...