نتایج جستجو برای: cyclopentanone

تعداد نتایج: 199  

Journal: :Acta pharmaceutica 2017
Mohammed Albratty Karam Ahmed El-Sharkawy Shamsher Alam

2-Cyano-N-(thiazol-2-yl) acetamide (2a) and 2-cyano-N-(oxazol2-yl) acetamide (2b) were obtained via the reaction of ethyl cyanoacetate with either 2-aminothiazole (1a) or 2-aminooxazole (1b). The formed products were directed toward the reaction with cyclopentanone and elemental sulfur in the presence of triethylamine to give cyclopenta[b]thiophene derivatives (3a,b). The latter products were r...

2013
Henrik U. Stotz Stefan Mueller Maria Zoeller Martin J. Mueller Susanne Berger

Jasmonates and phytoprostanes are oxylipins that regulate stress responses and diverse physiological and developmental processes. 12-Oxo-phytodienoic acid (OPDA) and phytoprostanes are structurally related electrophilic cyclopentenones, which activate similar gene expression profiles that are for the most part different from the action of the cyclopentanone jasmonic acid (JA) and its biological...

2012
Manabendra Dutta Choudhury Pankaj Chetia Karabi Dutta Choudhury Anupam Das Talukdar Mohan Datta-choudhari

There are over 600 million people worldwide covering Asian and Oceanic countries including India have the habit of chewing areca nut as masticator in different forms. Arecoline (C(8)H(13)NO(2)) has been reported as one of the abundant constituents of areca nut. A good number of scientific publications have made Arecoline responsible for oral cancer. Based on observation from clinical situation ...

2015
Hyunbeom Lee Emma H. Doud Rui Wu Ruslan Sanishvili Jose I. Juncosa Dali Liu Neil L. Kelleher Richard B. Silverman

γ-Aminobutyric acid aminotransferase (GABA-AT) is a pyridoxal 5'-phosphate (PLP)-dependent enzyme that degrades GABA, the principal inhibitory neurotransmitter in mammalian cells. When the concentration of GABA falls below a threshold level, convulsions can occur. Inhibition of GABA-AT raises GABA levels in the brain, which can terminate seizures as well as have potential therapeutic applicatio...

Journal: :Rheumatology 2008
E S Molloy M P Morgan G A Doherty B McDonnell M Hilliard J O'Byrne D J Fitzgerald G M McCarthy

OBJECTIVES Basic calcium phosphate (BCP) crystals have been implicated in the pathogenesis of OA and stimulate cyclo-oxygenase (COX) expression and PGE(2) production. This study aimed to elucidate the mechanism of COX-1 up-regulation by BCP crystals and to characterize the PGs produced in OA synovial fibroblasts (OASFs) in response to BCP crystals. METHODS OASFs were stimulated with BCP cryst...

2011
Ramin Miri Omidreza Firuzi Payam Peymani Zohreh Nazarian Abbas Shafiee

DNA intercalators belong to aromatic heterocyclic compounds interacting reversibly with DNA. These compounds have been used extremely as cytotoxic agents against cancer. In this study, the synthesis and biological activity of some novel derivatives of cyclopenta [b] quinoline-1, 8-dione as new intercalating agent were investigated. Twenty novel derivatives of cyclopenta [b] quinoline-1, 8-dione...

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