The complex [PtCl 2 (cyclohexane-1 R ,2 -diamine)] has been combined in a Pt(IV) molecule with two different bioactive molecules (i.e., the histone deacetylase inhibitor 2-propylpentanoic acid or valproic acid, VPA , and potential antimetastatic...

The conformation of hydroxy-γ-ionylideneacetic acids produced by Cercospora cruenta was examined by 'H-NMR analysis. (1)H-(1)H COSY and NOE data indicated that (2Z,4E,1'R,4'#)-4'-hydroxy-(γ)- ionylideneacetic acid has a cyclohexane ring of chair form furnishing a hydroxyl group and a 2,4-pentadienoic acid moiety, each with equatorial orientation, while (2Z,4E,1'S,3'S)-3'-hydroxy-γ-ionylideneace...

This paper reports the synthesis of three amine stereoisomers 5a-c of the tetrafluorocyclohexyl ring system, as building blocks for discovery chemistry programmes. The synthesis starts from a Birch reduction of benzonitrile, followed by an in situ methyl iodide quench. The resultant 2,5-cyclohexadiene was progressed via double epoxidations and then hydrofluorination ring opening reactions. The ...

Ethylhexyl triazone (ET) was separated from other sunscreens such as avobenzone, octocrylene, octyl methoxycinnamate, and diethylamino hydroxybenzoyl hexyl benzoate and from parabens by normal-phase HPTLC on silica gel 60 as stationary phase. Two mobile phases were particularly effective: (A) cyclohexane-diethyl ether 1 : 1 (v/v) and (B) cyclohexane-diethyl ether-acetone 15 : 1 : 2 (v/v/v) sinc...

The synthesis of a cyclohexane skeleton possessing different oxygenated functional groups at C-3, C-8 and C-9, and a D1,6-double bond has been accomplished in 10 steps with an overall 17% yield. This compound is a key intermediate for access to a wide range of compounds of the bioactive trisporoid family. The synthetic sequence consists of the preparation of a properly functionalized epoxygeran...

Chiral and C2-symmetric seven-membered cycloalkanones 2--6 bearing 1,2-diphenylethane-1,2-diamine and cyclohexane-1,2-diamine backbones were synthesized and evaluated their asymmetry inductive behaviours in an asymmetric epoxidation of stilbene with oxone. Although the reaction of the ketones 2 and 3 of a 1,2-diphenylethane-1,2-diamine backbone gave stilbene oxide in trace to 31% yield, those o...

In the present study, three new biobased furanoate polyesters with potential use in food packaging applications, named poly(isosorbide furanoate) (PIsF), poly(methyl-propylene furanoate) (PMePF) and poly(1,4-cyclohexane-dimethylene 2,5-furanoate) (PCHDMF) were synthesized. As monomers for the preparation of the polyesters, 2,5-furandicarboxylic acid (FDCA) and diols with irregular or complicate...

The relaxation of nuclear dipolar energy to the lattice has been measured in three different organic solids (benzene, cyclohexane and hexamethylbenzene) as a function of temperature. In the cases of C6H8 and C 6 (CH 3 ) 6 very slow motions associated with rather high activation energy were detected near the melting point. They are thought to be thermally activated rotations of the molecules abo...