The reaction of bis-(anthracene)cobaltate(-I) with excess cyclo-hepta-triene, C7H8, resulted in a new 18-electron cobaltate containing two different seven-membered ring ligands, based on single-crystal X-ray diffraction. The asymmetric unit of this structure contains two independent cation-anion pairs of the title complex, [K(18-crown-6)][Co(η(3)-C7H7)(η(5)-C7H9)], where 18-crown-6 stands for 1...

The title compound, C(45)H(34)O(4), is the product of a tandem 'pincer' Diels-Alder reaction consisting of two consecutive [4 + 2] cyclo-additions between two 2-benzofuran units and ethyl propiolate. The mol-ecule comprises a fused hexa-cyclic system containing four five-membered rings, which are in the usual envelope conformation, and two six-membered rings. In addition, four phenyl rings are ...

The four six-membered rings all adopt chair conformations in the two independent mol-ecules of the title cyclo-hexa-none cyclic diacetal with penta-erythritol, C(17)H(28)O(4).

Desmopressin acetate is a potent synthetic peptide hormone. A more acceptable route of Desmopressin acetate is a potent synthetic peptide hormone. That is administered via parenteral, intranasal, and oral routes. A more acceptable route of administration with potentially good bioavailability could be offered by transdermal delivery. The present work reports on the development of water-in-oil (w...

BACKGROUND Cancerous state is a highly stimulated environment of metabolically active cells. The cells under these conditions over express selective receptors for assimilation of factors essential for growth and transformation. Such receptors would serve as potential targets for the specific ligand mediated transport of pharmaceutically active molecules. The present study demonstrates the speci...

Targeted nano-drug delivery systems conjugated with specific ligands to target selective cell-surface receptors or transporters could enhance the efficacy of drug delivery and therapy. Transporters are expressed differentially on the cell-surface of different cell types, and also specific transporters are expressed at higher than normal levels in selective cell types under pathological conditio...

This presentation will give an overview of the current use of nanoparticles as drug carriers and will discuss their future use in drug targeting and drug delivery of active molecules. Today’s progress in cell biology and biotechnology enables scientists to synthesize highly active molecules to target specific intra-cellular receptors. The clinical use of such molecules is often very limited bec...

The title compound, C(16)H(16)O(8), is a potent nonspecific phyto-toxin. The crystal structure is the average of two tauto-mers, 5,6,7,9,10-penta-hydr-oxy-2-meth-oxy-7-methyl-1,4,5,6,7,8-hexa-hydro-anthracene-1,4-dione and 1,4,5,6,7-pentahydr-oxy-2-meth--oxy-7-methyl-5,6,7,8,9,10-hexa-hydro-anthracene-9,10-di-one. The cyclo-hexene rings in both tautomers display a half-chair conformation. An ex...

Supramolecular self-assembly provides ameans of achieving “bottom-up” fabrication of nanoscalematerials. Theirmechanical properties and functionality arise from the assembly of relatively simple molecular building blocks. These materials have selective affinity to different interfaces, high capacity for interfacial adsorption, nanostructure, and spontaneous formation of unique nano-self-assembl...