BACKGROUND Cycling and chronic tumor hypoxia are involved in tumor development and growth. However, the impact of cycling hypoxia and its molecular mechanism on glioblastoma multiforme (GBM) progression remain unclear. METHODOLOGY Glioblastoma cell lines, GBM8401 and U87, and their xenografts were exposed to cycling hypoxic stress in vitro and in vivo. Reactive oxygen species (ROS) production...

Potentially lethal damage (PLD) and its repair (PLDR) were studied in confluent human fibroblasts by analyzing the kinetics of chromosome break rejoining after X-ray or heavy-ion exposures. Cells were either held in the non-cycling G0 phase of the cell cycle for 12 h, or forced to proliferate immediately after irradiation. Fusion premature chromosome condensation (PCC) was combined with fluores...

Urban mobility is a prevalent problem in many cities around the world. Cycling offers a fast and cheap transportation option for short-distance trips, with smaller carbon and physical footprint than driving a car. Cycling can also encourage a modal shift from private car to public transport by providing efficient last mile connections. This has led to a renewed interest to promote cycling in ci...

The sensor networks consist of the smaller sensor nodes which automatically constructs the routes between themselves to form the data delivery paths.There are several methods of energy conservation such as clustering, routing, duty cycling and many others. The duty cycling or sleep wake cycling is incorporated for the minimization for energy consumption. The effective duty cycling procedure req...

Thirty patients with rapid cycling bipolar affective disorder were studied prospectively to assess presence and severity of thyroid hypofunction. Seven (23%) were classified as having grade I hypothyroidism, while 8 (27%) had grade II and 3 (10%) had grade III abnormalities. This prevalence of grade I hypothyroidism is significantly greater than that reported in studies of unselected bipolar pa...

BACKGROUND Pressure support ventilation (PSV) is a standard method for non-invasive home ventilation. A bench study was designed to compare the effectiveness of patient-ventilator inspiratory termination synchronization with automated and conventional triggering in various respiratory mechanics models. MATERIAL AND METHODS Two ventilators, the Respironics V60 and Curative Flexo ST 30, connected...

Lower-limb FES cycling for paraplegic and tetraplegic subjects has been previously described, with systems for both stationary ergometry and for mobile outdoor cycling being available. The potential therapeutic and medical benefits of FES cycling exercise have recently been surveyed [1]. A key finding is that regular FES cycling exercise leads to improved cardiopulmonary fitness, with a corresp...

In German cities, higher levels of education increase people’s propensity to cycle. However, it remains unknown whether this effect is restricted certain contexts, such as cities with low or medium cycling rates, a more universal occurrence. This paper develops and tests competing hypotheses on how the might depend overall level: (a) educational inequalities in could proportionally level (b) di...