The purpose of this work was to analyze chemokine and chemokine receptor expression in untreated and in irradiated squamous cell carcinoma of the head and neck (SCCHN) tumor cell lines, aiming at the establishment of assays to test for the relevance of chemokine and chemokine receptor expression in the response of SCCHN to radiotherapy and radiochemotherapy. Five low passage and 10 established ...

The successful resolution of inflammation is dependent upon the coordinated transition from the initial recruitment of neutrophils to a more sustained population of mononuclear cells. IL-6, which signals via the common receptor subunit gp130, represents a crucial checkpoint regulator of neutrophil trafficking during the inflammatory response by orchestrating chemokine production and leukocyte a...

Accumulating evidence suggests that spinal cord astrocytes play an important role in neuropathic pain sensitization by releasing astrocytic mediators (e.g. cytokines, chemokines and growth factors). However, it remains unclear how astrocytes control the release of astrocytic mediators and sustain late-phase neuropathic pain. Astrocytic connexin-43 (now known as GJ1) has been implicated in gap j...

The repetitive X-ray bursts from the accretion-powered pulsar GRO J1744−28 show similarities to the type II X-ray bursts from the Rapid Burster. Several authors (notably Lewin et al.) have suggested that the bursts from GRO J1744−28 are type II bursts (which arise from the sudden release of gravitational potential energy). In this paper, we present another similarity between these sources. Ross...

Diabetic nephropathy (DN) is a common microvascular complication that easily leads to end-stage renal disease. It important explore the key biomarkers and molecular mechanisms relevant diabetic (DN). We used highthroughput RNA sequencing obtain genes related DN glomerular tissues healthy of mice. Then we LIMMA analyze differentially expressed (DEGs) between non-diabetic samples. And performed K...

Abstract Background The tumor microenvironment (TME) has received an increasing amount of attention. CXC chemokines can regulate immune cell transport and activity to exert anti-tumor immunity. However, studies on the expression prognosis in cervical cancer (CC) are more limited. Methods study investigated role TME CC by using public databases. Moreover, quantitative real-time PCR (qRT-PCR) imm...