Cytochromes P-450 (P450s) are enzymes involved in the oxidative metabolism of a wide array of endogenous and exogenous molecules including steroids, plant metabolites, prostaglandins, biogenic amines, drugs, and chemical carcinogens. This broad spectrum of reactions is due to multiple P-450 isozymes with differing but overlapping substrate specificities. The mammalian P-450 superfamily consists...

So, this is the last Editorial I shall write as Editor of Seizure: hereafter, other Editors will impart their thoughts to you (assuming they write Editorials and you read them) and shape the future of the Journal. Something I started I now have to let go of and trust to others. Is that really possible? Of course it is. Seizure has come a long way in 13 years and I am proud to have been part of ...

Commercial load generation tools allow recording tier-to-tier communication and creating workloads via playback of the recorded script. Unfortunately, they do not work for all technologies. The alternative of creating a special test harness becomes more timeconsuming when faced with complicated scenarios and a need to analyze results. This paper discusses our experience using an intermediate ap...

This project is devoted to the study of fundamental techniques used in the development of both algorithms and representations for the conversion of functional specifications to custom integrated circuit layout specifications. Included in this area are five major areas of investigation. These are the development of functional specification languages, the development and utilization of architectu...

The incidence of breast cancer in Canada is continuing to rise. It was estimated that 23,600 new cases of breast cancer would be diagnosed in 2011 1. At the same time, it has been shown that, because of screening techniques, more women are surviving and living longer 2. In cancer rehabilitation, increased emphasis has therefore been placed on survivorship and on the treatment of the whole perso...

This comment is part of a symposium on Ekkehart Schlicht, On Custom in the Economy (1998) Oxford: Clarendon Press.