Chronic actinic dermatitis is a chronic photosensitivity disorder characterized by severe eczematous lesions on sun-exposed skin areas. We report a case of chronic actinic dermatitis presenting with leonine facies and secondary adrenal insufficiency, which was successfully treated with topical tacrolimus. The facial lesions dramatically improved after sun avoidance and topical tacrolimus applic...

A 35-year-old female was referred in Mai 1999 to our department for oligomenorrhea, baldness and weight gain evolving over 2 years. She doesn’t have any medical record and she is not taking any specific treatment especially corticosteroids. In her familial history, we found a sister and a niece with breast cancer and a brother died of colon cancer. The physical exam revealed a moon face, a mode...

Glucocorticoid (GC) excess, including Cushing's syndrome, is a common cause of secondary osteoporosis. Thirty to fifty percent of Cushing's syndrome patients experience non-traumatic fractures, which is often the presenting manifestation of Cushing's syndrome. However, there have been rare cases of Cushing's syndrome diagnosed only based upon bone manifestations. We describe a case of Cushing's...

CONTEXT Pseudoacromegaly describes conditions with an acromegaly related physical appearance without abnormalities in the growth hormone (GH) axis. Acromegaloid facies, together with hypertrichosis, are typical manifestations of Cantú syndrome. CASE DESCRIPTION We present a three-generation family with 5 affected members, with marked acromegaloid facies and prominent hypertrichosis, due to a ...

Cushing’s disease is bilateral adrenocortical hyperplasia secondary to excessive secretion of ACTH by the pituitary gland. Angio-oedema is due to oedema in the deeper subcutaneous and submucosal tissues. We report a patient with acquired angio-oedema which developed after transsphenoidal surgery for Cushing’s disease (CD). A 50-year-old woman admitted to the endocrinology department with a two-...

BACKGROUND To our knowledge, there have been no reports on the control of central nervous system symptoms in patients with ataxia-telangiectasia. OBJECTIVE To preliminarily determine the effectiveness of corticosteroid therapy on the central nervous system symptoms of a child with ataxia-telangiectasia in whom neurological signs improved when, occasionally, he was given betamethasone to treat...

The articles in this series address a fundamental question in pediatric psychology—whether children with chronic illnesses are generally psychologically well adjusted (or at least no more maladjusted than their peers) or whether their illness places them or their families at greater risk for emotional or behavioral difficulties. As the rich literature reviews of these three articles highlight, ...

Setial measurements of the bo(ly weight and the exchangeable sodium content were made in young pjatieIlts with acute lheumatic fever who weie being tieated with laige (loses of corticotropin. All lut one subject developed the clinical signs of hyperadrenalism. Eight of the 11 subjects showed at least a 20 per cent increase in body weight which could not be explained on the basis of the changes ...

Introduction: Microbial metabolic activity is significant in the cycling of phosphorus in aquatic and sedimentary environments. The requirement of microorganisms to use elemental phosphorous for energy transfer and to bind, concentrate and cause crystalliza-tion of phosphates is well established [e.g. 1,2]. The crystallization of phosphates in a sedimentary environment commonly occurs when the ...

The patient was a 61-year-old woman who had a well-differentiated pancreatic neuroendocrine tumor (PNET) with lymph node metastasis. After 15 months of octreotide treatment, glucose control deteriorated and pigmentation of the tongue and moon face developed, leading to the diagnosis of ectopic adrenocorticotropic hormone (ACTH) syndrome. An abnormal secretion of growth hormone (GH) was identifi...